(+)-7-methyl-5-phenyl-5,6,7,8-tetrahydro-furo[3,2-g]isoquinoline | 389845-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (+)-7-methyl-5-phenyl-5,6,7,8-tetrahydro-furo[3,2-g]isoquinoline
• 英文别名: Furo[3,2-g]isoquinoline, 5,6,7,8-tetrahydro-7-methyl-5-phenyl-；7-methyl-5-phenyl-6,8-dihydro-5H-furo[3,2-g]isoquinoline
• CAS: 389845-75-4
• 化学式: C₁₈H₁₇NO
• 分子量: 263.339
• InChiKey: FSXMAKUPPPDALQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  16.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
  申请人：Molino F. Bruce

  公开号：US20060111385A1

  公开（公告）日：2006-05-25

  The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

  本发明涉及一种治疗包括认知障碍、广泛性焦虑障碍、急性应激障碍、社交恐惧症、简单恐惧症、经前期情绪性失调障碍、社交焦虑障碍、重度抑郁障碍、进食障碍、肥胖症、厌食症、暴食症、物质滥用障碍、化学依赖、尼古丁成瘾、可卡因成瘾、酒精成瘾、安非他命成瘾、莱什-尼汉综合征、神经退行性疾病、月经后期综合征、嗜睡症、精神症状愤怒、拒绝敏感性、运动障碍、锥体外症候群、抽动障碍、不安腿综合征、迟发性运动障碍、与睡眠相关的进食障碍、夜间进食综合征、压力性尿失禁、偏头痛、神经痛、糖尿病性神经病变、纤维肌痛综合征、慢性疲劳综合征、性功能障碍、早泄和男性阳痿等多种疾病的方法。该方法涉及向需要此类治疗的患者施用所述化合物的治疗有效量。这些化合物是具有以下IA、IB、IIA、IIB、IIIA或IIIC式的4-苯基取代四氢异喹啉。
• Novel 4-phenyl substituted tetrahydroiso quinolines therapeutic use thereof
  申请人：——

  公开号：US20020091134A1

  公开（公告）日：2002-07-11

  Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

  提供了一些化合物，通过它们选择性的神经递质结合对治疗各种神经系统和心理障碍，例如注意力缺陷多动障碍（ADHD）具有益处。这些化合物是具有以下式子IA、IB、IIA、IIB、IIIA或IIIC的4-苯基取代的四氢异喹啉。
• NOVEL 4-PHENYL SUBSTITUTED TETRAHYDROISOQUINOLINES AND THERAPEUTIC USE THEREOF
  申请人：Beck James P.

  公开号：US20080318997A1

  公开（公告）日：2008-12-25

  Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

  提供了一些化合物，通过其选择性神经递质结合，用于治疗各种神经和心理障碍，例如注意力缺陷多动障碍（ADHD）。这些化合物是4-苯基取代的四氢异喹啉，其化学式为IA、IB、IIA、IIB、IIIA或IIIC。
• Use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence
  申请人：——

  公开号：US20040248925A1

  公开（公告）日：2004-12-09

  Provided herein are methods of using compounds of formula (IA, IB, IIA, IIB, IIIA, IIIB) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence.

  本文提供了使用式（IA、IB、IIA、IIB、IIIA、IIIB）化合物（芳基和杂芳基取代的四氢异喹啉）治疗慢性和神经性疼痛、治疗和预防偏头痛以及治疗压力性、急迫性和混合性尿失禁的方法。
• US7084152B2
  申请人：——

  公开号：US7084152B2

  公开（公告）日：2006-08-01