alpha-Aminoorcein | 642-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: alpha-Aminoorcein
• 英文别名: 7-amino-8-(2,4-dihydroxy-6-methylphenyl)-1,9-dimethylphenoxazin-3-one
• CAS: 642-61-5
• 化学式: C₂₁H₁₈N₂O₄
• 分子量: 362.4
• InChiKey: NNZHGEUZKBYASA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• [EN] NOVEL AZOMETHINE DIRECT DYES BEARING AT LEAST ONE CATIONIC CHARGE, COSMETIC COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF<br/>[FR] NOUVEAUX COLORANTS DIRECTS AZOMÉTHINIQUES PORTANT AU MOINS UNE CHARGE CATIONIQUE, COMPOSITION COSMÉTIQUE COMPRENANT AU MOINS UN TEL COLORANT, SON PROCÉDÉ DE MISE EN OEUVRE ET SON UTILISATION
  申请人：OREAL

  公开号：WO2018109192A1

  公开（公告）日：2018-06-21

  The present invention relates to novel cationic azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair: (I) (II) in which formula (I) or (II) X1, X2, R1, R2, R3, R4, R5, R6, n and n' are as defined in the description. The compounds of formula (I) according to the invention can give powerful, chromatic and sparingly selective colourings with good colour build-up, which are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

  本发明涉及一种新型的阳离子偶亚甲基直接染料，化学式为(I)，以及其对应的还原形式，化学式为(II)，并且涉及其用于染色角蛋白纤维，特别是人类角蛋白纤维，如头发：(I) (II)，其中化学式(I)或(II)中的X1、X2、R1、R2、R3、R4、R5、R6、n和n'的定义如描述中所述。根据本发明的化学式(I)的化合物可以提供强大、色彩丰富且具有良好上色效果的颜料，能够抵抗角蛋白纤维可能遭受的各种攻击因素，如恶劣天气、光线、洗涤和汗水。
• [EN] DISSYMMETRIC AZOMETHINE DIRECT DYES AND PROCESS FOR THEIR PREPARATION, COSMETIC COMPOSITION COMPRISING AT LEAST ONE SUCH DYE AND USE THEREOF<br/>[FR] COLORANTS DIRECTS AZOMÉTHINES DISSYMÉTRIQUES ET LEUR PROCÉDÉ DE PRÉPARATION, COMPOSITION COSMÉTIQUE COMPRENANT AU MOINS UN TEL COLORANT ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2018109153A1

  公开（公告）日：2018-06-21

  The present invention relates to dissymmetric azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair: in which formula (I) or (II) R1, R2, R3, R4, R5, R6, n and n' are as defined in the description. The compounds of formula (I) or (II) according to the invention can give powerful, chromatic and sparingly selective colourings with good colour build-up, which are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

  本发明涉及公式（I）的非对称偶氮亚甲基直接染料及其公式（II）的还原形式，以及其用于染色角蛋白纤维，特别是人类角蛋白纤维，如头发的用途：其中公式（I）或（II）中R1、R2、R3、R4、R5、R6、n和n'如描述中定义。根据本发明的公式（I）或（II）化合物可以提供强大、色彩丰富且具有良好色彩积累的染色效果，对角蛋白纤维可能受到的各种侵害因素具有抗性，如恶劣天气、光线、洗涤和汗水。
• AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES
  申请人：Michel Jean-Baptiste

  公开号：US20130243691A1

  公开（公告）日：2013-09-19

  The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.

  本发明涉及使用不可逆配体，所述配体为从白细胞弹性蛋白酶、凝血酶、组织型纤维蛋白原激活物（t-PA）和纤溶酶中选择的丝氨酸蛋白酶的配体，用于分子成像所述丝氨酸蛋白酶和诊断与所述丝氨酸蛋白酶活性相关的病理生理条件。
• [EN] A UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-TARGETING PEPTIDE<br/>[FR] PEPTIDE CIBLANT LE RÉCEPTEUR DE L'ACTIVATEUR DU PLASMINOGÈNE DE TYPE UROKINASE
  申请人：RIGSHOSPITALET

  公开号：WO2021009237A1

  公开（公告）日：2021-01-21

  The present invention describes a uPAR-targeting peptide conjugate comprising a fluorophore, a peptide binding to uPAR and a linker group which are connected by covalent bonds, wherein the uPAR-targeting peptide conjugate may be used as fluorescence probe in real time optical imaging and delineation of cancer tumors or metastases during surgery.

  本发明描述了一种uPAR靶向肽共轭物，包括荧光染料、结合uPAR的肽和连接它们的连接基团，它们由共价键连接，其中uPAR靶向肽共轭物可用作实时光学成像中的荧光探针，用于手术期间癌症肿瘤或转移的描绘。