[4-(5,6,7,8-Tetrahydronaphthalen-1-ylcarbamoyl)phenyl] 2-ethylbutanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: [4-(5,6,7,8-Tetrahydronaphthalen-1-ylcarbamoyl)phenyl] 2-ethylbutanoate
• 英文别名: [4-(5,6,7,8-tetrahydronaphthalen-1-ylcarbamoyl)phenyl] 2-ethylbutanoate
• 化学式: C₂₃H₂₇NO₃
• 分子量: 365.5
• InChiKey: NRKXFKCETRLRDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBUNIT SELECTIVE NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS<br/>[FR] ANTAGONISTES DU RÉCEPTEUR NMDA, SÉLECTIFS POUR DES SOUS-UNITÉS, ET DESTINÉS AU TRAITEMENT D'ÉTATS NEUROLOGIQUES
  申请人：UNIV EMORY

  公开号：WO2010088408A2

  公开（公告）日：2010-08-05

  Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-E, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.