1-(p-hydroxyphenyl)-1,3-propandiol | 22805-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-(p-hydroxyphenyl)-1,3-propandiol
• 英文别名: 1-(4-hydroxyphenyl)-1,3-propanediol；1-(4-Hydroxyphenyl)propane-1,3-diol；1-(4-hydroxyphenyl)propane-1,3-diol
• CAS: 22805-46-5
• 化学式: C₉H₁₂O₃
• 分子量: 168.192
• InChiKey: NTNORUCWSHQVSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 甲醇 、 potassium carbonate 作用下， 生成 1-(p-hydroxyphenyl)-1,3-propandiol
  参考文献：
  名称：

  使用高价碘试剂的未活化环丙烷的Lewis碱促进的开环1,3-二加氧反应

  摘要：

  已经开发了一种简便有效的系统，借助路易斯（Lewis）碱性促进剂对甲苯磺酰胺，通过[双（三氟乙酰氧基）碘]苯的CC键活化，对环丙烷的区域和化学选择性开环/亲电子官能化。所述p -toluenesulfonamide促进的系统可以很好地用于宽范围的环丙烷，得到1,3-二醇产物以良好产率选择性和区域选择性的形成。

  DOI：

  10.1002/anie.201713422

文献信息

• [EN] IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF<br/>[FR] COMPOSÉS À BASE D'IMIDAZO [1, 2-B] PYRIDAZINE, COMPOSITIONS LES COMPRENANT ET UTILISATIONS DE CEUX-CI
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2013134219A1

  公开（公告）日：2013-09-12

  Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

  基于咪唑并[1,2-b]吡啶嗪的化合物的公式（I）被披露，其中R1、R2和R3在此处被定义。还披露了包含这些化合物的组合物以及它们用于治疗、管理和/或预防由适配器相关激酶1活性介导的疾病和紊乱的方法。
• Arbutin Derivatives Isolated from Ancient Proteaceae: Potential Phytochemical Markers Present in <i>Bellendena</i>, <i>Cenarrhenes</i>, and <i>Persoonia</i> Genera
  作者：Bianca J. Deans、Nathan L. Kilah、Gregory J. Jordan、Alex C. Bissember、Jason A. Smith

  DOI：10.1021/acs.jnatprod.7b01038

  日期：2018.5.25

  species Bellendena montana, Cenarrhenes nitida, and Persoonia gunnii were conducted employing pressurized hot water extraction. As part of these studies, six novel glycosides were isolated, including rare examples of glycoside-containing natural products featuring tiglic acid esters. These polar molecules may represent potential phytochemical markers in ancient Proteaceae.

  使用加压热水提取法对塔斯马尼亚Proteaceae古流行物种Bendendena montana，Cenarrhenes nitida和Persoonia gunnii进行了广泛的植物化学研究。作为这些研究的一部分，分离了六种新的糖苷，包括罕见的以提花酸酯为特色的含糖苷天然产物的实例。这些极性分子可能代表了古代Proteaceae中潜在的植物化学标记。
• Electrochemical ring-opening 1,3-dihydroxylation of arylcyclopropanes with H₂O
  作者：Jianhua Cai、Yuxi Wen、Wei Sheng、Xuejin Huang、Ye Zheng、Chunlan Song、Jiakun Li

  DOI：10.1039/d3gc02283h

  日期：——

  dihydroxylation of alkenes is one of the most powerful synthetic tools for delivering two hydroxyl groups at vicinal positions. The direct formation of 1,3-diols remains a formidable challenge, yet dihydroxyl groups are broadly present in bioactive compounds, and are currently only available synthetically via multiple steps. The oxidative ring-opening of arylcyclopropanes has been demonstrated to access various

  传统的烯烃二羟基化是在邻位提供两个羟基的最强大的合成工具之一。直接形成 1,3-二醇仍然是一个艰巨的挑战，但二羟基广泛存在于生物活性化合物中，目前只能通过多个步骤合成。芳基环丙烷的氧化开环已被证明可以得到各种 1,3-双官能化化学物质，但由于 1,3-二醇本身很容易被进一步氧化，所以尚未直接合成 1,3-二醇。在此，我们报告了一种简便有效的 1,3-二醇策略，涉及用 H 2控制芳基环丙烷的电化学 C-C 键断裂O作为最终的绿色羟基源。此外，该方案以其高原子经济性、广泛的底物范围和优异的官能团耐受性而脱颖而出，因此适合复杂天然产物和药物衍生物的合成。
• IMIDAZO [1, 2 - B]PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP2822559A1

  公开（公告）日：2015-01-14
• METHOD FOR TIERED PRODUCTION OF BIOBASED CHEMICALS AND BIOFUELS FROM LIGNIN
  申请人：Peterson John R.

  公开号：US20130232852A1

  公开（公告）日：2013-09-12

  The present invention is directed generally to a method of production of value-added, biobased chemicals from lignin sources, including waste lignin. A method of using a depolymerization of lignin to create a tiered production of biobased aromatic chemicals and biofuels is also described herein. The method described herein may also allow for the selective production of the biobased aromatic chemicals and biofuels. Additionally, a reduction of waste products may also be provided from the present method.