calactin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: calactin
• 英文别名: 3a,11,11a-Trihydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydro-3-furanyl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde；9,10,22-trihydroxy-7,18-dimethyl-19-(5-oxo-2H-furan-3-yl)-4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-14-carbaldehyde
• 化学式: C₂₉H₄₀O₉
• 分子量: 532.631
• InChiKey: OWPWFVVPBYFKBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Topical and oral formulations of cardiac glycosides for treating skin diseases
  申请人：Streeper Robert

  公开号：US20060205679A1

  公开（公告）日：2006-09-14

  The present invention provides method, preparation and use of a variety of pharmaceutical compositions containing at least one digitalis glycoside such as oleandrin, odoroside-A, neriifolin, proscillaridin-A, methyl-proscillaridin-A, digitoxin, digoxin alone or at least one digitalis glycoside complexed with cyclodextrins. In another aspect, the present invention provides an effective method to treat diseases in mammals. In yet another aspect, the present invention provides an effective method for treating skin diseases in a human or non-human animal.

  本发明提供了一种方法、制备和使用多种含有至少一种毛地黄苷类药物成分的药物组合物，例如奥利安定、奥多罗苷A、内里福林、普罗斯西拉里丁A、甲基普罗斯西拉里丁A、地高辛、地高辛或至少一种毛地黄苷类与环糊精络合的药物。另一方面，本发明提供了一种有效的方法来治疗哺乳动物的疾病。另一方面，本发明提供了一种有效的方法来治疗人类或非人类动物的皮肤疾病。
• [EN] 2" OXO-VORUSCHARIN AND DERIVATIVES THEREOF<br/>[FR] 2" OXO-VORUSCHARINE ET DERIVES DE CETTE DERNIERE
  申请人：UNIBIOSCREEN SA

  公开号：WO2004033465A1

  公开（公告）日：2004-04-22

  The present invention relates to the novel compound 2'' oxo-voruscharin and derivatives. In addition, the present invention relates to pharmaceutical compositions comprising the novel 2'' oxo-voruscharin or derivatives. The present invention further relates to the 2'' oxo-voruscharin and derivatives for use as a medicament and for use in the preparation of a medicament for treating cancer. The present invention also relates to a method of treating cancer.

  本发明涉及新型化合物2''氧代-沃鲁沙林及其衍生物。此外，本发明涉及包含新型2''氧代-沃鲁沙林或其衍生物的制药组合物。本发明还涉及将2''氧代-沃鲁沙林及其衍生物用作药物，并用于制备治疗癌症的药物。本发明还涉及一种治疗癌症的方法。
• 2''oxo-voruscharin and analogues thereof
  申请人：Unibioscreen S.A.

  公开号：EP1408043A1

  公开（公告）日：2004-04-14

  The present invention relates to the novel compound 2" oxo-voruscharin and analogues. In addition, the present invention relates to pharmaceutical compositions comprising the novel 2" oxo-voruscharin or analogues. The present invention further relates to the 2" oxo-voruscharin and analogues for use as a medicament and for use in the preparation of a medicament for treating cancer. The present invention also relates to a method of treating cancer.

  本发明涉及新型化合物 2 "氧代姜黄素及其类似物。此外，本发明还涉及包含新型 2 "氧代姜黄素或类似物的药物组合物。本发明进一步涉及用作药物和用于制备治疗癌症的药物的 2 "氧代-voruscharin 及类似物。本发明还涉及一种治疗癌症的方法。
• Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances
  申请人：Direvo Biotech AG

  公开号：EP1726643A1

  公开（公告）日：2006-11-29

  The present invention provides a method for the selection of proteases with altered sensitivity to one or more activity-modulating substances. The method combines the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.

  本发明提供了一种选择对一种或多种活性调节物质敏感性改变的蛋白酶的方法。该方法包括提供编码多核苷酸序列的蛋白酶文库、表达酶、在一种或多种活性调节物质存在下筛选文库、选择对一种或多种活性调节物质敏感性改变的变体以及分离编码所选变体的多核苷酸序列。
• Serine proteases with altered sensitivity to activity-modulating substances
  申请人：Direvo Biotech AG

  公开号：EP2045321A2

  公开（公告）日：2009-04-08

  The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.

  本发明提供了对一种或多种活性调节物质敏感性改变的 S1 类丝氨酸蛋白酶变体。本发明公开了一种生成此类蛋白酶的方法，包括提供编码多核苷酸序列的蛋白酶文库，表达酶，在一种或多种活性调节物质存在下筛选文库，选择对一种或多种活性调节物质敏感性改变的变体，以及分离编码所选变体的多核苷酸序列。