2-methyl-(2H)-thiapyran | 15165-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: 2-methyl-(2H)-thiapyran
• 英文别名: 2-Methyl-1-thio-α-pyran；2-methyl-2H-thiopyran；2-methyl-2H-thiopyran
• CAS: 15165-13-6
• 化学式: C₆H₈S
• 分子量: 112.196
• InChiKey: OYDIECGUBNPZFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-Methyl-2-thia-bicyclo[3.1.0]hex-3-ene 500.0 ℃ 、13.33 Pa 条件下， 生成 2-methyl-(2H)-thiapyran 、 3-Methyl-2H-thiopyran
  参考文献：
  名称：

  Klaerner, Frank-Gerrit; Schroeer, Dietmar, Angewandte Chemie, 1987, vol. 99, # 12, p. 1295 - 1297

  摘要：

  DOI：

文献信息

• Orally Bioavailable Caffeic Acid Related Anticancer Drugs
  申请人：Priebe Waldemar

  公开号：US20070232668A1

  公开（公告）日：2007-10-04

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗细胞增殖性疾病如癌症的用途。本发明的化合物作为Jak2/STAT3途径和下游靶点的抑制剂显示出显著的效力，并抑制癌细胞系的生长和存活。
• NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS)
  申请人：Board of Regents, The University of Texas System

  公开号：US20140228414A1

  公开（公告）日：2014-08-14

  Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

  提供了在调节STAT3和/或STAT5激活方面有效的吡啶化合物，这些化合物在预防和治疗增生性疾病和病症中包括癌症、炎症和增生性皮肤疾病方面具有用处。
• ORALLY BIOAVAILABLE CAFFEIC ACID RELATED ANTICANCER DRUGS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20150094343A1

  公开（公告）日：2015-04-02

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗细胞增殖性疾病，例如癌症。本发明的化合物作为Jak2 / STAT3途径及下游靶点的抑制剂具有显著的效力，并抑制癌细胞系的生长和存活。
• Polymer catalyst transducers and use thereof in test kits for analytical methods
  申请人：MILES INC.

  公开号：EP0140322A2

  公开（公告）日：1985-05-08

  Polymer-catalyst tranducers and their use for detecting one or more constituents in a sample are disclosed. Changes in conductivity of the polymercatalyst transducers as a result of electron density changes are measured to provide an indication of a particular constituent present in the sample. Such conductivity changes can be measured using a conductivity meter. The polymer-catalyst tranducers are particularly useful for the determination of glucose in whole blood.

  本发明公开了聚合物催化剂诱导体及其用于检测样品中一种或多种成分的方法。通过测量电子密度变化引起的聚合物催化剂传感器电导率的变化，可以显示样品中存在的特定成分。这种电导率变化可以使用电导率仪进行测量。聚合物催化剂诱导体特别适用于测定全血中的葡萄糖。
• Orally bioavailable cafeic acid related anticancer drugs
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2514742A2

  公开（公告）日：2012-10-24

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

  本发明涉及化合物及其用于治疗癌症等细胞增殖性疾病。本发明的化合物作为 Jak2/STAT3 通路和下游靶点的抑制剂具有显著的效力，可抑制癌细胞株的生长和存活。