4-(Dihydroxyamino)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(Dihydroxyamino)phenol
• 化学式: C₆H₇NO₃
• 分子量: 141.12
• InChiKey: PCROLJXVCVCKBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES
  申请人：Holmes Christopher P.

  公开号：US20090048147A1

  公开（公告）日：2009-02-19

  The present invention relates to a compound comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The linker moiety is between the peptide moiety and the water-soluble polymer moiety. In certain embodiments, the linker moiety has the structure: wherein α, β, and γ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein κ, ρ, and τ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein χ, φ, γ, and η are each integers whose values are independently selected. Alternatively, the linker structure may have the following structure: wherein λ and μ are each integers whose values are independently selected.

  本发明涉及一种化合物，包括肽基团、连接基团和水溶性聚合物基团，例如聚乙二醇基团。连接基团位于肽基团和水溶性聚合物基团之间。在某些实施例中，连接基团具有以下结构：其中α、β和γ分别是独立选择的整数。在其他实施例中，连接基团具有以下结构：其中κ、ρ和τ分别是独立选择的整数。在其他实施例中，连接基团具有以下结构：其中χ、φ、γ和η分别是独立选择的整数。或者，连接结构也可以具有以下结构：其中λ和μ分别是独立选择的整数。
• SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B
  申请人：Mnemosyne Pharmaceuticals, Inc.

  公开号：US20150225342A1

  公开（公告）日：2015-08-13

  Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

  本发明公开了选择性负向调节含有NR1/NR2B亚基的NMDA受体的化合物，包括该化合物的制药组合物，以及使用该化合物治疗疾病的方法。
• Hair dye coupler and process for making
  申请人：Bristol-Myers Company

  公开号：EP0215560A1

  公开（公告）日：1987-03-25

  A substituted m-aminophenol coupler useful in hair dyeing havina the formula and acid addition salts thereof wherein x and y are selected from the group consisting of halogen and the groups OR of which R ist the same or different alkyl, aminoalkyl of hydroxylalkyl groups, at least one for x or y being a group OR and a process for preparing these compounds.

  一种用于染发的取代间氨基苯酚偶联剂，其式及其酸加成盐，其中 x 和 y 选自卤素和基团 OR（其中 R 是相同或不同的烷基、氨基烷基或羟基烷基）组成的组，x 或 y 中至少有一个是基团 OR，以及制备这些化合物的工艺。
• MULTIFUNCTIONAL STEALTH NANOPARTICULES FOR BIOMEDICAL USE
  申请人：Schneider Grégory F.

  公开号：US20120082728A1

  公开（公告）日：2012-04-05

  The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
• Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules
  申请人：Holmes Christopher P.

  公开号：US20120165275A1

  公开（公告）日：2012-06-28

  Compounds comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety are disclosed. Various linker moieties for use in these compounds are also disclosed, along methods for their synthesis.