ethyl 3-(3,4-dihydroxyphenyl)lactate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: ethyl 3-(3,4-dihydroxyphenyl)lactate
• 英文别名: Ethyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: PFNTZFUZCHVMEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 ethyl 3-(3,4-dihydroxyphenyl)lactate 以 乙醚 为溶剂， 生成 2-hydroxy-3-(3,4-dimethoxyphenyl)propanoic acid ethyl ester
  参考文献：
  名称：

  荆芥的三种新酚类化合物

  摘要：

  三种新的酚类化合物，2-(glycer-2-yl)-5-(2-羟乙基)苯基-O-β-D-吡喃葡萄糖苷、2-(glycer-2-yl)-5-(2-羟乙基)苯基-O-β-D-吡喃半乳糖苷和 3-(3,4-二羟基苯基)乳酸乙酯从 Nepeta prattii 中分离得到。它们的结构是通过光谱方法阐明的。

  DOI：

  10.1002/jccs.200200039

文献信息

• A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol
  作者：Aya Fujimoto、Yoshimi Shingai、Mitsuhiro Nakamura、Tomomi Maekawa、Yoshiaki Sone、Toshiya Masuda

  DOI：10.1016/j.bmcl.2010.10.040

  日期：2010.12

  The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product. The structure of the active product in the oxidation product mixture was determined using extensive NMR spectroscopy to have a novel oxygen-containing seven-membered ring system. The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed. (C) 2010 Elsevier Ltd. All rights reserved.
• Three New Phenolic Compounds from<i>Nepeta Prattii</i>
  作者：Zhen-Fu Hou、Yong-Qiang Tu、Yu Li

  DOI：10.1002/jccs.200200039

  日期：2002.4

  Three new phenolic compounds, 2-(glycer-2-yl)-5-(2-hydroxyethyl)phenyl-O-β-D-glucopyranoside, 2-(glycer-2-yl)-5-(2-hydroxyethyl)phenyl-O-β-D-galactopyranoside and ethyl 3-(3,4-dihydroxyphenyl)lactate were isolated from Nepeta prattii. Their structures were elucidated by spectral methods.

  三种新的酚类化合物，2-(glycer-2-yl)-5-(2-羟乙基)苯基-O-β-D-吡喃葡萄糖苷、2-(glycer-2-yl)-5-(2-羟乙基)苯基-O-β-D-吡喃半乳糖苷和 3-(3,4-二羟基苯基)乳酸乙酯从 Nepeta prattii 中分离得到。它们的结构是通过光谱方法阐明的。