1,3,6,8,10,11-Hexahydroxy-naphthacene-5,12-dione | 220736-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 1,3,6,8,10,11-Hexahydroxy-naphthacene-5,12-dione
• 英文别名: 1,3,6,8,10,11-Hexahydroxytetracene-5,12-dione
• CAS: 220736-88-9
• 化学式: C₁₈H₁₀O₈
• 分子量: 354.273
• InChiKey: PHYUQMBGSCMYTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1,3,6,8,10,11-Hexahydroxy-naphthacene-5,12-dione 在 吡啶 作用下， 生成 Acetic acid 3,8,10-triacetoxy-5,12-dihydroxy-6,11-dioxo-6,11-dihydro-naphthacen-1-yl ester 、 Acetic acid 1,3,8,10-tetraacetoxy-12-hydroxy-6,11-dioxo-6,11-dihydro-naphthacen-5-yl ester 、 Acetic acid 2,4,7,9,12-pentaacetoxy-6,11-dioxo-6,11-dihydro-naphthacen-5-yl ester
  参考文献：
  名称：

  Novel Selective Inhibitors for Human Topoisomerase I, BM2419-1 and -2 Derived from Saintopin.

  摘要：

  Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.

  DOI：

  10.7164/antibiotics.51.1069

文献信息

• JPH11246469A
  申请人：——

  公开号：JPH11246469A

  公开（公告）日：1999-09-14
• Novel Selective Inhibitors for Human Topoisomerase I, BM2419-1 and -2 Derived from Saintopin.
  作者：DAISUKE ISHIYAMA、KATUYUKI FUTAMATA、MATIKO FUTAMATA、OSAMU KASUYA、SHINYA KAMO、FUMIO YAMASHITA、SUSUMU KANAZAWA

  DOI：10.7164/antibiotics.51.1069

  日期：——

  Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.