[1-[10,11-Dihydroxy-4,6,12,17,17-pentamethyl-18-(3,4,5-trihydroxyoxan-2-yl)oxy-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docosan-8-yl]-2-hydroxy-2-methylpropyl] acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [1-[10,11-Dihydroxy-4,6,12,17,17-pentamethyl-18-(3,4,5-trihydroxyoxan-2-yl)oxy-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docosan-8-yl]-2-hydroxy-2-methylpropyl] acetate
• 化学式: C₃₇H₆₀O₁₁
• 分子量: 680.9
• InChiKey: PJGMIZSCETWMLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  48
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  175
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：Findeis Mark A.

  公开号：US20110136750A1

  公开（公告）日：2011-06-09

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• [EN] COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSÉS UTILES POUR TRAITER DES MALADIES NEURODÉGÉNÉRATIVES
  申请人：SATORI PHARMACEUTICAL INC

  公开号：WO2008063165A1

  公开（公告）日：2008-05-29

  [EN] As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
  [FR] Telle que décrite ici, la présente invention concerne des composés utiles pour traiter ou diminuer la gravité d'une maladie neurodégénérative. La présente invention concerne également des procédés de traitement ou de diminution de la gravité de telles maladies, ledit procédé consistant à administrer à un patient un composé de la présente invention ou une composition de celui-ci. Ledit procédé est utile pour traiter ou diminuer la gravité, par exemple, de la maladie d'Alzheimer.