methyl 3-methoxy-3H-benzo[f]chromene-2-carboxylate | 1010721-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: methyl 3-methoxy-3H-benzo[f]chromene-2-carboxylate
• CAS: 1010721-84-2
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: KNAYSWZLLZWEDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 N-(2-hydroxynaphthalen-1-yl)-methylene-4-methylbenzenesulfonamide 、 三甲基硅烷丙炔甲酯 在 三乙烯二胺 、 3 A molecular sieve 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 methyl 3-methoxy-3H-benzo[f]chromene-2-carboxylate
  参考文献：
  名称：

  Three-Component Coupling Reaction and Cyclization of N-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO

  摘要：

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.

  DOI：

  10.1021/jo702649q

文献信息

• Three-Component Coupling Reaction and Cyclization of <i>N</i>-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO
  作者：Yuji Matsuya、Kousuke Hayashi、Akiho Wada、Hideo Nemoto

  DOI：10.1021/jo702649q

  日期：2008.3.1

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.