3a-Androstane-diol | 87099-93-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3a-Androstane-diol
• 英文别名: (3R,8R,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
• CAS: 87099-93-2
• 化学式: C₁₉H₃₂O₂
• 分子量: 292.462
• InChiKey: CBMYJHIOYJEBSB-HQEGDXSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHODS OF TREATING OR PREVENTING ESTROGEN-RELATED DISEASES
  申请人：Endorecherche, Inc.

  公开号：EP2582371A1

  公开（公告）日：2013-04-24
• [EN] BONE ANABOLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES ANABOLISANTS OSSEUX ET LEURS PROCEDES D'UTILISATION
  申请人：——

  公开号：WO2003002058A9

  公开（公告）日：2004-07-08

  [EN] A variety of bone anabolic compounds are useful for maintaining and/or increasing bone mass, density, and/or strength in mammals. Preferred compounds enhance bone anabolic activity while minimizing or eliminating undesirable feminizing or masculinizing effects.
  [FR] L'invention concerne une variété de composés anabolisants que l'on peut utiliser pour conserver et/ou augmenter la masse, la densité et/ou la résistance osseuses chez les mammifères. Les composés préférés renforcent l'activité anabolisante osseuse tout en réduisant ou en éliminant les effets féminisants ou masculinisants indésirables.
• [EN] METHODS OF TREATING OR PREVENTING ESTROGEN-RELATED DISEASES<br/>[FR] MÉTHODES DE TRAITEMENT PROPHYLACTIQUE OU THÉRAPEUTIQUE DE MALADIES LIÉES AUX OESTROGÈNES
  申请人：ENDORECH INC

  公开号：WO2011156908A1

  公开（公告）日：2011-12-22

  Methods for treating or reducing the likelihood of acquiring estrogen -related (e.g. estrogen-exacerbated) diseases including endometriosis include administering to a patient a selective estrogen receptor modulator (SERM), in combination with inhibiting ovarian secretions, e.g., by administering an LHRH agonist or antagonist. In some embodiments, a precursor of sex steroids, said precursor being selected from the group consisting of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA- S), androst-5-ene-3β,17β-diol (5-diol), and androstenedione or a compound transformed into one of these, is also administered