Lactucopikrin | 6466-74-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Lactucopikrin
• 英文别名: (4-hydroxy-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[8,7-b]furan-9-yl)methyl 2-(4-hydroxyphenyl)acetate
• CAS: 6466-74-6
• 化学式: C₂₃H₂₂O₇
• 分子量: 410.423
• InChiKey: QCDLLIUTDGNCPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS FOR TREATING COMPULSIVE-LIKE BEHAVIOR IN A SUBJECT
  申请人：UNIVERSITY OF THE SCIENCES

  公开号：US20190054067A1

  公开（公告）日：2019-02-21

  The present invention includes methods of treating obsessive-compulsive disorder and/or an obsessive-compulsive related disorder or disease. The present invention further includes methods of treating symptoms of a compulsive-like behavior, obsessive-compulsive related disorder, and/or compulsive-like behaviors in an autism spectrum disorder or disease. In certain embodiments, the method comprises administering to the subject a therapeutically effective amount of a positive allosteric α4β2 nicotinic acetylcholine receptor modulator, alone or in combination with another positive allosteric α4β2 nicotinic acetylcholine receptor modulator or an additional agent known to treat the symptoms of obsessive-compulsive disorder, an obsessive-compulsive related disorder, and/or compulsive-like behaviors in autism spectrum disorder or disease.