1,3,8,10,11-Pentahydroxy-6-methyl-naphthacene-5,12-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 1,3,8,10,11-Pentahydroxy-6-methyl-naphthacene-5,12-dione
• 英文别名: 1,3,8,10,11-Pentahydroxy-6-methyltetracene-5,12-dione
• 化学式: C₁₉H₁₂O₇
• 分子量: 352.3
• InChiKey: QPTIGEXZMBTRSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1,3,8,10,11-Pentahydroxy-6-methyl-naphthacene-5,12-dione 在 吡啶 作用下， 生成 Acetic acid 3,8,10-triacetoxy-12-hydroxy-5-methyl-6,11-dioxo-6,11-dihydro-naphthacen-1-yl ester
  参考文献：
  名称：

  Novel Selective Inhibitors for Human Topoisomerase I, BM2419-1 and -2 Derived from Saintopin.

  摘要：

  Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.

  DOI：

  10.7164/antibiotics.51.1069

文献信息

• Novel Selective Inhibitors for Human Topoisomerase I, BM2419-1 and -2 Derived from Saintopin.
  作者：DAISUKE ISHIYAMA、KATUYUKI FUTAMATA、MATIKO FUTAMATA、OSAMU KASUYA、SHINYA KAMO、FUMIO YAMASHITA、SUSUMU KANAZAWA

  DOI：10.7164/antibiotics.51.1069

  日期：——

  Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.