4-methyl-quinazoline-2-carboxylic acid amide | 13535-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-methyl-quinazoline-2-carboxylic acid amide
• 英文别名: 4-Methyl-chinazolin-2-carbonsaeure-amid；4-Methylquinazoline-2-carboxamide
• CAS: 13535-92-7
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: RNRDSFASSMRPKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  盐酸 、 4-methyl-quinazoline-2-carboxylic acid amide 生成 (6CI,7CI,8CI,9CI)-4-甲基喹唑啉 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Bogert; Nabenhauer, Journal of the American Chemical Society, 1924, vol. 46, p. 1705,1933

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-acetyl-phenyl)-oxalamide 在 氨 作用下， 生成 4-methyl-quinazoline-2-carboxylic acid amide
  参考文献：
  名称：

  Bogert; Nabenhauer, Journal of the American Chemical Society, 1924, vol. 46, p. 1705,1933

  摘要：

  DOI：

文献信息

• Methods and compositions for treatment of cancer and autoimmune disease
  申请人：THE JACKSON LABORATORY

  公开号：US10207988B2

  公开（公告）日：2019-02-19

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.

  本文所述技术涉及诱导细胞死亡的方法。本文所述技术还涉及通过施用双链断裂修复抑制剂来治疗包括癌症和自身免疫性疾病在内的疾病。本文还描述了双链断裂修复抑制剂和筛选此类抑制剂的方法。
• METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE
  申请人：The Jackson Laboratory

  公开号：EP2724156A1

  公开（公告）日：2014-04-30
• EP2724156B1
  申请人：——

  公开号：EP2724156B1

  公开（公告）日：2017-08-16
• [EN] METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER ET D'UNE MALADIE AUTO-IMMUNE
  申请人：JACKSON LAB

  公开号：WO2013003112A1

  公开（公告）日：2013-01-03

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.
• [EN] COMPOUNDS AND METHODS TO TARGET GLUCOSE-STIMULATED PHOSPHOHISTIDINE SIGNALING AND ESOPHAGEAL CANCER GROWTH<br/>[FR] COMPOSÉS ET MÉTHODES POUR CIBLER LA SIGNALISATION DE LA PHOSPHOHISTIDINE STIMULÉE PAR LE GLUCOSE ET LA CROISSANCE DU CANCER DE L'ŒSOPHAGE
  申请人：[en]HEALTH RESEARCH, INC.

  公开号：WO2022109469A1

  公开（公告）日：2022-05-27

  Provided are compounds and compositions that inhibit glucose-induced growth signaling and methods of using same. The compounds may be suitable to treat glycolytic cancers, such as, for example, esophageal squamous cell carcinoma (ESCC). The compounds may be used to inhibit or partially inhibit glucose-promoted tumor cell proliferation, NME-1 catalyzed histidine phosphorylation of FAK, and FAK interaction with RBI. The compounds may have the following structure: