(17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl) acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl) acetate
• 化学式: C₂₄H₃₂O₄
• 分子量: 384.5
• InChiKey: RQZAXGRLVPAYTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS FOR DETERMINING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS
  申请人：Analiza, Inc.

  公开号：EP3702783A1

  公开（公告）日：2020-09-02

  Some embodiments of the present invention generally relate to devices and methods for determining and/or isolating cells. For example, one aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e. g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

  本发明的一些实施方案一般涉及用于确定和/或分离细胞的装置和方法。例如，一个方面一般涉及用于检测、识别、计数和/或可能分选血液或其他生物样本中相关细胞的方法和装置。在某些实施方案中，血液样本（或其他生物液体）可以用信号实体（如 pH 敏感实体）处理，这些实体会变色或在合适的内部环境中产生信号。例如，某些细胞（如癌细胞或胎儿细胞）与其他细胞相比，细胞内 pH 值可能存在差异，可使用 pH 值敏感实体进行检测。在某些实施方案中，可根据此类信号实体对细胞进行分选；例如，在用于分选细胞的合适机器中对细胞进行照射（如使用荧光灯），可对细胞进行测定，在某些情况下，还可对细胞进行回收或分离，以便进一步操作。
• Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
  申请人：Emory University

  公开号：US10286113B2

  公开（公告）日：2019-05-14

  The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as clotrimazole, honokiol, magnolol, tacrolimus, pimecrolimus, sirolimus, everolimus, temsirolimus, spironolactone, fluticasone, fluticasone propionate, fluticasone furoate, linezolid, telmisartan, chlorambucil, retinol, isotretinoin, acitretin, etretinate, retinoic acid (tretinoin), teniposide, mitomycin C, cytarabine, decitabine, vinblastine, vincristine, vindesine, vinorelbine, valrubicin, doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxantrone, pixantrone, plicamycin, pazopanib, topotecan, camptothecin, irinotecan, sunitinib, derivatives, or salt thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.

  本公开涉及用于骨形成、骨折治疗、骨移植、骨融合、软骨维护和修复的化合物和组合物及其相关方法。在某些实施方案中，本公开涉及包含一种或多种本文公开的化合物的组合物，例如克霉唑、霍诺酚、麦格诺尔、他克莫司、吡美莫司、西罗莫司、依维莫司、西罗莫司、依维莫司、替米考酚酯、螺内酯、氟替卡松、丙酸氟替卡松、糠酸氟替卡松、利奈唑胺、替米沙坦、氯霉素、视黄醇、异维A酸、阿曲汀、依曲替酸、维A酸、维甲酸、替尼泊苷、丝裂霉素 C、阿糖胞苷、地西他滨、长春新碱、长春瑞滨、长春瑞滨、长春瑞滨、瓦鲁比星、多柔比星、达诺比星、表柔比星、依达比星、伊达比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、多柔比星、依达比星、依达比星、米托蒽醌、匹蒽醌、普利霉素、帕唑帕尼、拓扑替康、喜树碱、伊立替康、舒尼替尼、衍生物或其盐，用于骨生长过程。在一个典型的实施方案中，骨移植组合物被植入受试者所需骨生长或增强的部位。
• METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS
  申请人：Analiza, Inc.

  公开号：EP3080341B1

  公开（公告）日：2020-02-12
• SOLUBILIZED FLAVONOID COMPOSITION
  申请人：Technology Investments LC

  公开号：EP3345594B1

  公开（公告）日：2021-11-17
• FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING
  申请人：Ramachandra Sumant

  公开号：US20110097340A1

  公开（公告）日：2011-04-28

  Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.

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