6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester
• 化学式: C16H12N2O6
• InChiKey: RZKNRCBVLASAPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  129.84
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester 在 氢氧化钾 作用下， 以 水 为溶剂， 生成 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester potassium salt
  参考文献：
  名称：

  US4657909

  摘要：

  公开号：

文献信息

• Antimicrobial and antitumor phenazine carboxaldehydes and derivatives
  申请人：Warner-Lambert Company

  公开号：US04657909A1

  公开（公告）日：1987-04-14

  Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

  来源于6-甲酰基-4,7,9-三羟基-1-苯并咔啉羧酸甲酯和6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺表现出抗微生物和抗肿瘤活性。一株纯化的Streptomyces galanosa NRRL 15738菌株能够从含有可吸收的碳和氮源的发酵液中产生可分离的6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯。
• Purified culture of streptomyces galanosa
  申请人：Warner-Lambert Company

  公开号：US04738929A1

  公开（公告）日：1988-04-19

  Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate anti-microbial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

  6-甲酰基-4,7,9-三羟基-1-苯并咔啉羧酸甲酯和6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯所衍生的酸、酯、亚胺酸、亚胺酯和亚胺酰胺表现出抗微生物和抗肿瘤活性。一种纯化的链霉菌菌株Streptomyces galanosa，编号NRRL 15738，能够从含有可同化的碳和氮源的发酵液中产生可分离的6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯。