12-Hydroxyoctadecyl hydrogen sulfate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 12-Hydroxyoctadecyl hydrogen sulfate
• 化学式: C₁₈H₃₈O₅S
• 分子量: 366.6
• InChiKey: SRNZFQJWLFVECZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  24
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS<br/>[FR] UTILISATION D'INHIBITEURS DE MÉTALLOPROTÉINASE MATRICIELLE DANS LE TRAITEMENT DE LA TUBERCULOSE
  申请人：UNIV COLUMBIA

  公开号：WO2012112945A1

  公开（公告）日：2012-08-23

  The present invention provides a method for treating a subject suffering from tuberculosis which comprises administering to the subject a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to treat the subject, such that the therapeutic effect of said composition is different than the therapeutic effect attributable to the antibiotic properties of said composition. The present invention also provides a method for reducing or inhibiting destruction of lung extracellular matrix in a subject comprising administering to the subject at risk for such destruction a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to reduce or inhibit destruction of lung extracellular matrix in the subject.