2-[1-[4-[2-(3,5-dihydroxy-2-methylidenecyclohexylidene)ethylidene]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-1-yl]ethoxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-[1-[4-[2-(3,5-dihydroxy-2-methylidenecyclohexylidene)ethylidene]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-1-yl]ethoxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide
• 化学式: C₂₆H₃₄F₅NO₄
• 分子量: 519.5
• InChiKey: SVCSMAZYWOQCBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS
  申请人：Puretech Health LLC

  公开号：EP3548005A1

  公开（公告）日：2019-10-09
• MILK VESICLES FOR USE IN DELIVERING BIOLOGICAL AGENTS
  申请人：PureTech LYT, Inc.

  公开号：US20210290538A1

  公开（公告）日：2021-09-23

  The present disclosure provides milk vesicles as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within or otherwise associated with the milk vesicles, methods of producing such milk vesicles and compositions thereof, as well as methods of delivering such milk vesicles and compositions to a specific patient tissue or organ. Also provided herein is a composition comprising milk vesicles, wherein the milk vesicles comprise a lipid membrane to which one or more proteins are associated, and wherein (a) a relative abundance of casein in the composition is less than about 40%, and/or (b) a relative abundance of lactoglobulin in the composition is less than about 25%.
• [EN] EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] EXOSOMES DESTINÉS À L'ADMINISTRATION D'AGENTS THÉRAPEUTIQUES
  申请人：PURETECH HEALTH LLC

  公开号：WO2018102397A1

  公开（公告）日：2018-06-07

  The present invention provides exosomes as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to a specific patient tissue or organ. The present invention also provides methods of treating a disease, disorder, or condition such as cancer, an inflammatory disease, an infectious disease, an allergic disease, or an autoimmune disease, comprising administering to a patient in need thereof a provided therapeutic-loaded exosome or a pharmaceutical composition thereof.