10-formyl-folic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 10-formyl-folic acid
• 英文别名: 10-Formyl Folic Acid；2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
• 化学式: C₂₀H₁₉N₇O₇
• 分子量: 469.414
• InChiKey: UGWUWNVTCLDEOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  217
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  active charcoal 、 10-formyl-folic acid 生成 calcium 5-methyl-(6S)-tetrahydrofolate pentahydrate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Process For The Preparation Of Optically Pure Tetrahydropterins And Derivatives, And Specifically Of Optically Pure Tetrahydrofolic Acid And Derivatives Thereof, By Stereospecific Hydrogenation
  申请人：MULLER Hans Rudolf

  公开号：US20080306263A1

  公开（公告）日：2008-12-11

  Process for the preparation of tetrahydropterin and tetrahydropterin derivatives by hydrogenating pterin and pterin derivatives with hydrogen in the presence of a hydrogenating catalyst, in which the hydrogenation is carried out in a polar reaction medium and metal complexes that are soluble in the reaction medium are employed as the hydrogenation catalysts. The process is suited to the hydrogenation, particularly asymmetric hydrogenation, of folic acid, folio acid salts, folio acid esters, folio acid ester salts or dihydroforms thereof, with the proviso that in the event of using folic acid, carboxylic acid salts thereof or dihydroforms thereof the reaction medium is aqueous, and in the event of using folic acid esters, folic acid ester salts or dihydroforms thereof the reaction medium is an alcohol. The process opens up straightforward access to achiral and chiral pterin derivatives.

  通过在存在氢化催化剂的情况下，用氢气氢化葉酸和葉酸衍生物制备四氢生物葉酸和四氢生物葉酸衍生物的过程，其中氢化是在极性反应介质中进行的，并且可溶于反应介质的金属配合物被用作氢化催化剂。该过程适用于葉酸、葉酸盐、葉酸酯、葉酸酯盐或其二氢形式的氢化，特别是不对称氢化，但若使用葉酸、其羧酸盐或二氢形式，则反应介质为水，若使用葉酸酯、葉酸酯盐或其二氢形式，则反应介质为醇。该过程为得到无手性和手性葉酸衍生物提供了直接途径。
• Compositions comprising pantothenic acid or derivatives thereof and their use for stimulating appetite
  申请人：N.V. Nutricia

  公开号：EP2002830A1

  公开（公告）日：2008-12-17

  The present invention relates to the field of food compositions. In particular compositions comprising at least 15 En% protein and pantothenic acid, or equivalents thereof, are provided, which are suitable for stimulating appetite.

  本发明涉及食品组合物领域。特别是提供了由至少 15 En% 的蛋白质和泛酸或其等价物组成的组合物，适用于刺激食欲。
• 5-METHYLFOLATE PRODUCING MICROORGANISM
  申请人：Chifeng Pharmaceutical Co., Ltd

  公开号：EP3940071A1

  公开（公告）日：2022-01-19

  The present invention provides a 5-methylfolate producing microorganism which a) has been modified to have a decreased expression and/or activity of a polypeptide having both dihydrofolate synthase activity and folylpolyglutamate synthetase activity compared to an otherwise identical microorganism (reference microorganism); b) has been (further) modified to express a heterologous polypeptide having only dihydrofolate synthase activity; c) has been (further) modified to have an increased expression level of at least one enzyme (such as at least two, at least three, at least four, at least five, at least six, at least seven or at least eight) enzymes involved in the biosynthesis of a 5-methylfolate compared to an otherwise identical microorganism (reference microorganism); and/or d) has been (further) modified to have a decreased expression and/or activity of a polypeptide having 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity compared to an otherwise identical microorganism (reference microorganism).

  本发明提供了一种生产 5-甲基叶酸的微生物，该微生物 a)与其他相同的微生物（参考微生物）相比，已被修饰为具有二氢叶酸合成酶活性和聚谷氨酸合成酶活性的多肽的表达量和/或活性降低； b)已（进一步）修饰为表达仅具有二氢叶酸合成酶活性的异源多肽；c) 已被(进一步)修饰，与其它相同微生物(参考微生物)相比，参与 5-甲基叶酸盐生物合成的至少一种酶(如至少两种、至少三种、至少四种、至少五种、至少六种、至少七种或至少八种)的表达水平提高；和/或 d）经（进一步）改造，与其它相同微生物（参考微生物）相比，具有 5-甲基四氢特戊酰基三谷氨酸-高半胱氨酸 S-甲基转移酶活性的多肽的表达量和/或活性降低。
• Compositions containing vitamin D and magnesium
  申请人：Tucker Matthew Scott

  公开号：US10183031B2

  公开（公告）日：2019-01-22

  Described herein are manufactured compositions that contain vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg. A manufactured composition contains vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg and N-acetyl-L-cysteine magnesium chelate in the amount of 75 mg. A manufactured composition contains vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg and N-acetyl-L-cysteine magnesium chelate in the amount of 75 mg, and iron.

  本文描述的人造组合物含有量为 3500 IU 至 5000 IU 的维生素 D 和量为约 1 毫克的 L-5-甲基四氢叶酸镁形式的镁。一种人造组合物含有含量为 3500 IU 至 5000 IU 的维生素 D 和含量为约 1 毫克的 L-5-甲基四氢叶酸镁和含量为 75 毫克的 N-乙酰-L-半胱氨酸镁螯合物。一种人造组合物含有含量为 3500 IU 至 5000 IU 的维生素 D 和含量为约 1 毫克的 L-5-甲基四氢叶酸镁和含量为 75 毫克的 N-乙酰-L-半胱氨酸镁螯合物形式的镁，以及铁。
• VERFAHREN ZUR HERSTELLUNG VON OPTISCH REINEN TETRAHYDROPTERINEN UND DERIVATEN, IM SPEZIELLEN OPTISCH REINER TETRAHYDROFOLSÄURE UND IHREN DERIVATEN, DURCH STEREOSPEZIFISCHE HYDRIERUNG
  申请人：EPROVA AG Forschungsinstitut

  公开号：EP1200437B1

  公开（公告）日：2004-03-10