Allo-cholesterol | 517-10-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Allo-cholesterol
• 英文别名: cholest-4-en-3β-ol；Cholest-4-en-3-ol；10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 517-10-2；14597-42-3
• 化学式: C₂₇H₄₆O
• 分子量: 386.662
• InChiKey: UIMGHSAOLFTOBF-UHFFFAOYSA-N

物化性质

• 熔点：
  132°
• 比旋光度：
  D23 +43.7° (c = 1 in benzene)
• 沸点：
  452.8°C (rough estimate)
• 密度：
  0.9610 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS
  申请人：Haelters Jean-Pierre

  公开号：US20130178609A1

  公开（公告）日：2013-07-11

  The present invention relates to fluorescent and/or targeting lipophilic compounds having the general formula (R1O)(R2O)P(O)—R3-R4-R5 wherein R1 and R2 are each independently a linear or branched, saturated or unsaturated C2-C24 alkyl, or a linear or branched, saturated or unsaturated C2-C24 monoalkenyl or polyalkenyl, the polyalkenyl having from 2 to 4 double bonds, or a linear or branched, saturated or unsaturated C2-C24 monoalkinyl or polyalkinyl, the polyalkinyl having from 2 to 4 triple bonds; R3 is selected from 0, S, —C(R6)2-, —CH(R7)-, —C(S)—N(R6)-, —CH(SR7)-S—S— or —N(R6)- wherein R6 is a hydrogen atom or a C1-C4 alkyl, and R7 is a C1-C4 alkyl; R4 comprises at least one junction function and at least one linker; and R5 is at least one chemical fluorescent group or at least one targeting group. Methods for preparing said lipophilic compounds are also disclosed.

  本发明涉及具有一般式（R1O）（R2O）P（O）-R3-R4-R5的荧光和/或靶向性亲脂性化合物，其中R1和R2各自独立地为线性或支链的饱和或不饱和的C2-C24烷基，或线性或支链的饱和或不饱和的C2-C24单烯基或多烯基，多烯基具有2至4个双键，或线性或支链的饱和或不饱和的C2-C24单炔基或多炔基，多炔基具有2至4个三键；R3从0，S，-C（R6）2-，-CH（R7）-，-C（S）-N（R6）-，-CH（SR7）-S-S-或-N（R6）-中选择，其中R6是氢原子或C1-C4烷基，R7是C1-C4烷基；R4包括至少一个连接功能和至少一个连接基；R5至少是一个化学荧光基团或至少一个靶向基团。本发明还公开了制备上述亲脂性化合物的方法。
• Linear polyethylenimine-sterol conjugates for gene delivery
  申请人：The University of Utah Research Foundation

  公开号：US20040137050A1

  公开（公告）日：2004-07-15

  Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian cells transfected with these complexes showed protein expression levels higher than linear polyethylenimine alone, and twice that of branched polyethylenimine, but without any significant loss in cell viability. Methods of making these compositions and methods of using them for gene delivery are also described.

  线性聚乙烯亚胺被固醇（如胆固醇）以三种不同的几何形状进行改性：线性形状（L）、T形状（T）和线性和T形状的组合（LT），从而形成线性聚乙烯亚胺-固醇共轭物。这些共轭物与核酸混合形成复合物，用于将核酸传递到细胞中。转染这些复合物的哺乳动物细胞显示出比单独使用线性聚乙烯亚胺更高的蛋白表达水平，且比支化聚乙烯亚胺高出一倍，但没有任何显著的细胞存活率损失。还描述了制备这些组合物的方法以及将其用于基因传递的方法。
• SYNTHETIC GLYCOLIPID-CONTAINING LIPOSOMES
  申请人：Katayama Chemical Industries Co., Ltd.

  公开号：EP2255787A1

  公开（公告）日：2010-12-01

  The present invention provides a glycolipid-containing liposome. In such a glycolipid-containing liposome, the glycolipid includes a plant ceramide portion and a sugar chain portion. The present invention also provides a method of producing a glycolipid-containing liposome. This method includes the following steps of: A) providing a glycolipid in which the glycolipid includes a plant ceramide portion and a sugar chain portion; and B) mixing the provided glycolipid with a liposome raw material and subjecting the mixture to conditions in which a liposome is formed.

  本发明提供了一种含糖脂的脂质体。在这种含糖脂的脂质体中，糖脂包括植物神经酰胺部分和糖链部分。本发明还提供了一种生产含糖脂脂质体的方法。该方法包括以下步骤：A）提供一种糖脂，其中糖脂包括植物神经酰胺部分和糖链部分；以及B）将所提供的糖脂与脂质体原料混合，并将混合物置于形成脂质体的条件下。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Gpib-lipid bond construct and use thereof
  申请人：——

  公开号：US20030113262A1

  公开（公告）日：2003-06-19

  The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing this conjugate and a free lipid. The GPIb lipid complex is expected to have a potential for practical application in a wide range, as a platelet substitute, a pharmaceutical agent for the prophylaxis or treatment of angiopathy, vascular damage and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent thereof. Moreover, the GPIb lipid complex of the present invention is also superior in retention property in blood, which enables continuous expression of a pharmacological action. The conjugate of the present invention is highly utilizable as an active ingredient of the GPIb lipid complex of the present invention.

  本发明提供了一种共轭物，其中 GP（糖蛋白）Ib 和脂质通过聚环氧烷键合在一起。本发明还提供了一种复合物（GPIb 脂质复合物），其中含有这种共轭物和一种游离脂质。GPIb 脂质复合物有望在广泛的范围内具有实际应用潜力，可用作血小板替代物、预防或治疗血管病变、血管损伤和血栓形成的药物制剂、vWF 缺乏症等的诊断剂、生物或医疗试剂、血小板聚集抑制剂或抗血栓形成筛选试剂等。本发明的 GPIb 脂质复合物还可用作寻找血管病变或血栓形成位置的诊断试剂或其治疗剂。此外，本发明的 GPIb 脂质复合物在血液中的保留性能也很优越，可持续发挥药理作用。本发明的共轭物作为本发明 GPIb 脂质复合物的活性成分具有很高的利用价值。