N-methyl-1-(3,4-ethylenedioxyphenyl)-2-aminopropane | 133787-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-methyl-1-(3,4-ethylenedioxyphenyl)-2-aminopropane
• 英文别名: 3,4-ethylenedioxymethamphetamine；(±)-1-(3,4-ethylenedioxyphenyl)-N-methyl-2-aminopropane；EDMA；Ethylenedioxymethylamphetamine；1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methylpropan-2-amine
• CAS: 133787-66-3
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: UJKWLAZYSLJTKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-1-(3,4-ethylenedioxyphenyl)-2-aminopropane 在 盐酸 作用下， 以 乙醚 、 乙醇 为溶剂， 以0.03 g的产率得到(±)-1-(3,4-ethylenedioxyphenyl)-N-methyl-2-aminopropane hydrochloride
  参考文献：
  名称：

  Ethylenedioxy homologs of N -methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine

  摘要：

  N-Methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA; 'Ecstasy'; 1) and its beta-keto analog methylone (MDMC; 2) are popular drugs of abuse. Little is known about their ring-expanded ethylenedioxy homologs. Here, we prepared N-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (EDMA; 3), both of its optical isomers, and beta-keto EDMA (i.e., EDMC; 4) to examine their effects at transporters for serotonin (SERT), dopamine (DAT), and norepinephrine (NET). In general, ring-expansion of the methylenedioxy group led to a several-fold reduction in potency at all three transporters. With respect to EDMA (3), S(+)3 was 6-fold, 50-fold, and 8-fold more potent than its R(-) enantiomer at SERT, DAT, and NET, respectively. Overall, in the absence of a beta-carbonyl group, the ethylenedioxy (i.e., 1,4-dioxane) substituent seems better accommodated at SERT than at DAT and NET. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.07.035
• 作为产物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 N-methyl-1-(3,4-ethylenedioxyphenyl)-2-aminopropane
  参考文献：
  名称：

  Ethylenedioxy homologs of N -methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine

  摘要：

  N-Methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA; 'Ecstasy'; 1) and its beta-keto analog methylone (MDMC; 2) are popular drugs of abuse. Little is known about their ring-expanded ethylenedioxy homologs. Here, we prepared N-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (EDMA; 3), both of its optical isomers, and beta-keto EDMA (i.e., EDMC; 4) to examine their effects at transporters for serotonin (SERT), dopamine (DAT), and norepinephrine (NET). In general, ring-expansion of the methylenedioxy group led to a several-fold reduction in potency at all three transporters. With respect to EDMA (3), S(+)3 was 6-fold, 50-fold, and 8-fold more potent than its R(-) enantiomer at SERT, DAT, and NET, respectively. Overall, in the absence of a beta-carbonyl group, the ethylenedioxy (i.e., 1,4-dioxane) substituent seems better accommodated at SERT than at DAT and NET. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.07.035

文献信息

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  申请人：UNIV MARYLAND

  公开号：WO2016061571A1

  公开（公告）日：2016-04-21

  Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.

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• Method for fabrication of biochips with a macroporous polymer substrate
  申请人：Kukhtin V. Alexander

  公开号：US20050042363A1

  公开（公告）日：2005-02-24

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  申请人：Self Colin Henry

  公开号：US20100209295A1

  公开（公告）日：2010-08-19

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  本发明公开了适用于测定半抗原的液滴试纸和其他测定装置。还公开了用于这种装置的阻断剂。
• Surfactant-Based Monolithic Columns, Methods for Making the Same, and Method for Using the Same
  申请人：Shamsi Shahab Ahmed

  公开号：US20110086409A1

  公开（公告）日：2011-04-14

  A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.

  提供了一种制备基于表面活性剂的单体柱的方法。该方法包括提供一种混合物，其中包括至少一种表面活性剂单体、至少一种交联剂、至少一种引发剂和至少一种孔原。将该混合物聚合成表面活性剂基的单体柱。本公开还提供了一种基于表面活性剂的单体柱、分离分子的方法和制备表面活性剂单体的过程。
• COMPOSITION FOR FORMING A DEVELOPABLE BOTTOM ANTIREFLECTIVE COATING
  申请人：NAKASUGI Shigemasa

  公开号：US20140193753A1

  公开（公告）日：2014-07-10

  The present invention provides a composition for forming a bottom anti-reflective coating, and also provides a photoresist pattern formation method employing that composition. The composition gives a bottom anti-reflective coating used in a lithographic process for manufacturing semiconductor devices, and the coating can be developed with a developing solution for photoresist. The composition contains a solvent, a polymer having a condensed polycyclic aromatic group, and a compound having a maleimide derivative or a maleic anhydride derivative. The composition may further contain a photo acid generator or a crosslinking agent.

  本发明提供一种用于形成底部抗反射涂层的组合物，并提供一种采用该组合物的光阻图案形成方法。该组合物可用于制造半导体器件的光刻过程中的底部抗反射涂层，并且可用光阻显影液进行显影。该组合物包含溶剂、具有紧缩多环芳香基团的聚合物以及具有马来酰亚胺衍生物或马来酸酐衍生物的化合物。该组合物还可以进一步包含光酸发生剂或交联剂。