mangostenone D

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: mangostenone D
• 英文别名: 5,9,11-Trihydroxy-3,3-dimethyl-10-(3-methylbut-2-enyl)-1,2-dihydropyrano[3,2-a]xanthen-12-one
• 化学式: C₂₃H₂₄O₆
• 分子量: 396.44
• InChiKey: VEUQWGPUUYXBDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  mangostenone D 在 polyphosphoric acid 、 air 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以89%的产率得到BR-氧杂蒽酮 A
  参考文献：
  名称：

  用多磷酸活化酚氧原子：含羰基的二氢苯并呋喃/二氢苯并吡喃的合成

  摘要：

  摘要 通过使用多磷酸（PPA）活化酚氧原子，由含羰基的邻烯丙基/异戊烯基苯酚制备含羰基的二氢苯并呋喃/二氢苯并吡喃。研究了各种底物，并以良好至优异的产率获得了相应的二氢苯并呋喃/二氢苯并吡喃。

  DOI：

  10.1080/00397911.2021.1902537

文献信息

• NUTRACEUTICAL COMPOSITION FROM GARCINIA MANGOSTANA
  申请人：Gokaraju Ganga Raju

  公开号：US20100298423A1

  公开（公告）日：2010-11-25

  Pharmaceutical, cosmetic, nutraceutical and dietary compositions derived from Garcinia mangostana are rich in γ-mangostin and other demethylated xanthones. These compositions exhibit potent antioxidative activity and reduce inflammation. These compositions may be used in a method of treating TNF-α, and aP2 mediated disorders. The compositions are prepared by subjecting a hydroalcoholic extract of fruit pericarp (fruit hull) of Garcinia mangostana , wherein said hydroalcoholic extract comprises predominantly α-mangostin, to demethylation in the presence of a Lewis acid, an organic base and a catalyst.
• Activation of phenolic oxygen atom using polyphosphoric acid: Synthesis of carbonyl-containing dihydrobenzofurans/dihydrobenzopyrans
  作者：Qian Yang、Yu Wang、Juan Yang、Yi Wu、Liang-qun Li、Fa-ju Chen、En-hua Wang、Li-lang Li、Yan Yang、Yan-fang Yan、Li Wang、Li-juan Ge、Li-shou Yang、Xiao-sheng Yang

  DOI：10.1080/00397911.2021.1902537

  日期：——

  Abstract Carbonyl-containing dihydrobenzofurans/dihydrobenzopyrans were prepared from carbonyl-containing ortho-allyl/prenylphenols by activation of phenolic oxygen atom using polyphosphoric acid (PPA). Various substrates were investigated, and the corresponding dihydrobenzofurans/dihydrobenzopyrans were obtained in good to excellent yields.

  摘要 通过使用多磷酸（PPA）活化酚氧原子，由含羰基的邻烯丙基/异戊烯基苯酚制备含羰基的二氢苯并呋喃/二氢苯并吡喃。研究了各种底物，并以良好至优异的产率获得了相应的二氢苯并呋喃/二氢苯并吡喃。