2-(1-hydroxyethyl)-4-(3-methyloxiran-2-yl)-2H-furan-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 2-(1-hydroxyethyl)-4-(3-methyloxiran-2-yl)-2H-furan-5-one
• 化学式: C₉H₁₂O₄
• 分子量: 184.19
• InChiKey: VMLNPJDEXLLCQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Means and methods for controlling commensales
  申请人：B.R.A.I.N. Biotechnology Research and Information Network AG

  公开号：EP2090292A1

  公开（公告）日：2009-08-19

  This invention relates to a cosmetic composition comprising or consisting of one or more compounds selected from the compounds of formulae (A) and (B) wherein ---- represents a single bond or double bond; R1 in formula (A) and R1 in formula (B) are selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, linear or branched C1 to C4 alkinyl, and linear or branched C1 to C4 alkanoyl; R3 in formula (A) and R3 in formula (B) are selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, and linear or branched C1 to C4 alkinyl; R2 and R4 in formula (A) are independently selected from H, OH and halogen, or R2 and R4 together are O to form an epoxid, wherein ---- represents a single bond in case R2 and R4 together are O; and R2 and R4 in formula (B) are defined as R2 and R4 in formula (A), respectively.

  本发明涉及一种化妆品组合物，该组合物由一种或多种选自式 (A) 和 (B) 化合物的化合物组成。 其中 ---- 代表单键或双键；式 (A) 中的 R1 和式 (B) 中的 R1 选自 H、直链或支链 C1 至 C4 烷基、直链或支链 C1 至 C4 烯基、直链或支链 C1 至 C4 烷基和直链或支链 C1 至 C4 烷酰基；式 (A) 中的 R3 和式 (B) 中的 R3 选自 H、直链或支链 C1 至 C4 烷基、直链或支链 C1 至 C4 烯基和直链或支链 C1 至 C4 烷基；式（A）中的 R2 和 R4 独立选自 H、OH 和卤素，或 R2 和 R4 同为 O 以形成环氧化合物，其中 ---- 在 R2 和 R4 同为 O 的情况下代表单键；式（B）中的 R2 和 R4 分别定义为式（A）中的 R2 和 R4。
• MEANS AND METHODS FOR CONTROLLING COMMENSALES
  申请人：B.R.A.I.N.

  公开号：EP2268260A1

  公开（公告）日：2011-01-05
• [EN] MEANS AND METHODS FOR CONTROLLING COMMENSALES<br/>[FR] MOYENS ET PROCÉDÉS DE LUTTE CONTRE LES COMMENSAUX
  申请人：B R A I N

  公开号：WO2009103501A1

  公开（公告）日：2009-08-27

  This invention relates to a cosmetic composition comprising or consisting of one or more compounds selected from the compounds of formulae (A) and (B) wherein ---- represents a single bond or double bond; R1 in formula (A) and R1 in formula (B) are selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, linear or branched C1 to C4 alkinyl, and linear or branched C1 to C4 alkanoyl; R3 in formula (A) and R3 in formula (B) are selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, and linear or branched C1 to C4 alkinyl; R2 and R4 in formula (A) are independently selected from H, OH and halogen, or R2 and R4 together are O to form an epoxid, wherein ---- represents a single bond in case R2 and R4 together are O; and R2 and R4 in formula (B) are defined as R2 and R4 in formula (A), respectively. Preferably, said cosmetic composition is for the cleaning of the skin. Also provided are means and methods for the prevention or reduction of biofilm formation on an intracorporeal device and/or for the removal of biofilm from an intracorporeal device, wherein said biofilm comprises or consists of bacteria of the genus Propionibacterium. Furthermore provided is an intracorporeal device which is coated and/or loaded with one or more compounds as defined above.