Pregna-4,16-dien-3,20-dion

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Pregna-4,16-dien-3,20-dion
• 英文别名: 17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₂₈O₂
• 分子量: 312.452
• InChiKey: VRRHHTISESGZFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• VACCINE ADJUVANTS
  申请人：Cadila Pharmaceuticals Ltd.

  公开号：EP2337847B1

  公开（公告）日：2015-12-02
• Vaccine Adjuvants
  申请人：Khamar Bakulesh Mafatlal

  公开号：US20110182939A1

  公开（公告）日：2011-07-28

  The invention provides novel adjuvants and pharmaceutical composition comprising of an adjuvant alone. The invention also provides novel vaccine compositions comprising of an antigen and a novel adjuvant. The novel adjuvant as per present invention is farnesoid-X-receptor (FXR) antagonist. The invention also relates to an adjuvant for variety of antigens. The adjuvant improves antibody production specific to incorporated antigen. The adjuvant also induces cell mediated immune response.
• US8647643B2
  申请人：——

  公开号：US8647643B2

  公开（公告）日：2014-02-11
• [EN] VACCINE ADJUVANTS<br/>[FR] ADJUVANTS POUR DES VACCINS
  申请人：CADILA PHARMACEUTICALS LTD

  公开号：WO2010035119A2

  公开（公告）日：2010-04-01

  The invention provides novel adjuvants and pharmaceutical composition comprising of an adjuvant alone. The invention also provides novel vaccine compositions comprising of an antigen and a novel adjuvant. The novel adjuvant as per present invention is farnesoid-X-receptor (FXR) antagonist. The invention also relates to an adjuvant for variety of antigens. The adjuvant improves antibody production specific to incorporated antigen. The adjuvant also induces cell mediated immune response.