2-amino-7-(4-methoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-7-(4-methoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
• 英文别名: 2-amino-7-(4-methoxyphenyl)-7,8-dihydro-6H-quinazolin-5-one
• 化学式: C₁₅H₁₅N₃O₂
• 分子量: 269.3
• InChiKey: VUGWFHHXRWKZKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS FOR DELAYING OCCURRENCE OF NEW-ONSET TYPE 2 DIABETES AND FOR SLOWING PROGRESSION OF AND TREATING TYPE 2 DIABETES
  申请人：DalCor Pharma UK Ltd Leatherhead, Zug Branch

  公开号：EP3833336A1

  公开（公告）日：2021-06-16
• PREVENTIVE AND THERAPEUTIC DRUG FOR CARTILAGINOUS HYPERPLASIA AND METHOD OF SCREENING FOR THE SAME
  申请人：KYOTO UNIVERSITY

  公开号：US20160177406A1

  公开（公告）日：2016-06-23

  A method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia and a therapeutic and/or preventive drug for cartilaginous hyperplasia are provided. The following are provided: a method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising a step of culturing chondroprogenitor cells under conditions in which the cells are brought into contact with a test substance and conditions in which the cells are not brought into contact with the test substance and a step of determining the SOX9 promoter activity, cAMP level, or degree of phosphorylation of CREB in the cells or the extracellular matrix volume in a culture; and a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising as an active ingredient an adenylate cyclase inhibitor.
• METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS
  申请人：DALCOR PHARMA UK LTD., STOCKPORT ZUG BRANCH

  公开号：US20190070178A1

  公开（公告）日：2019-03-07

  The invention provides compositions and methods useful for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events.
• US9921212B2
  申请人：——

  公开号：US9921212B2

  公开（公告）日：2018-03-20
• [EN] METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS<br/>[FR] MÉTHODES DE TRAITEMENT OU DE PRÉVENTION DE TROUBLES CARDIOVASCULAIRES ET D'ABAISSEMENT DU RISQUE D'ÉVÉNEMENTS CARDIOVASCULAIRES
  申请人：DALCOR PHARMA UK LTD STOCKPORT ZUG BRANCH

  公开号：WO2019043018A1

  公开（公告）日：2019-03-07

  The invention provides compositions and methods useful for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events.