5-Methyldihydrofolic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 5-Methyldihydrofolic acid
• 英文别名: 2-[[4-[(2-amino-5-methyl-4-oxo-3,8-dihydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• 化学式: C₂₀H₂₃N₇O₆
• 分子量: 457.4
• InChiKey: VWNDXSYYCICZGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  199
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• COMPOSITIONS COMPRISING FOLIC ACID DERIVATIVES, THEIR PREPARATIONS AND METHODS OF USE
  申请人：CHEMIC LABORATORIES INC.

  公开号：US20170121333A1

  公开（公告）日：2017-05-04

  Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.

  本文描述了制备叶酸衍生物的方法、中间体、制药组合物及其用途。
• Synthesis of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid
  申请人：Jones S. Gerald

  公开号：US20070190596A1

  公开（公告）日：2007-08-16

  A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.

  一种用于大规模化学酶法生产(6S)-5-甲基-5,6,7,8-四氢叶酸，也称为(6S)-5-甲基THFA的方法，包括以下步骤：(1)还原叶酸(FA)以产生二氢叶酸(DHFA)；(2)在存在NADP/NADPH、葡萄糖和GluDH的情况下，用二氢叶酸还原酶(DHFR)对DHFA进行立体选择性还原，以产生(6S)-THFA；(3)将(6S)-THFA转化为(6S)-5-甲基THFA；(4)分离(6S)-5-甲基THFA。
• Synthesis of (6S)-5methyl-5,6,7,8-tetrahydrofolic acid
  申请人：Jones, JR. Gerald S.

  公开号：US20100151533A1

  公开（公告）日：2010-06-17

  A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.

  一种大规模化学酶法生产(6S)-5-甲基-5,6,7,8-四氢叶酸，也称为(6S)-5-甲基THFA的方法，包括以下步骤：(1)还原叶酸(FA)以产生二氢叶酸(DHFA)；(2)在NADP/NADPH、葡萄糖和GluDH存在下，用二氢叶酸还原酶(DHFR)立体选择性地还原DHFA以产生(6S)-THFA；(3)将(6S)-THFA转化为(6S)-5-甲基THFA；(4)分离(6S)-5-甲基THFA。
• SYNTHESIS OF (6S)-5,6,7,8-TETRAHYDROFOLIC ACID
  申请人：Jones, JR. Gerald S.

  公开号：US20120315679A1

  公开（公告）日：2012-12-13

  A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA,

  一种用于大规模化学酶生产（6S）-5-甲基-5,6,7,8-四氢叶酸，也称为（6S）-5-甲基THFA的方法，包括以下步骤：（1）还原叶酸（FA）以产生二氢叶酸（DHFA）；（2）在NADP / NADPH，葡萄糖和GluDH的存在下，用二氢叶酸还原酶（DHFR）立体选择性地还原DHFA，从而产生（6S）-THFA；（3）将（6S）-THFA转化为（6S）-5-甲基THFA；以及（4）分离（6S）-5-甲基THFA。
• Formulation of amorphous calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca)
  申请人：Chemo Research, S.L.

  公开号：EP2781214A1

  公开（公告）日：2014-09-24

  The present invention relates to a dosage form which comprises amorphous calcium L-5-methylfolate and cysteine as stabilizing agent and optionally, further auxiliary agents. The dosage forms according to the invention resolves the problem of unstability of amorphous calcium L-5-methylfolate to the oxidation by air.

  本发明涉及一种剂型，它包括无定形的 L-5-甲基叶酸钙和作为稳定剂的半胱氨酸，以及可选的其他辅助剂。 本发明的剂型解决了无定形 L-5- 甲基叶酸钙在空气中氧化不稳定的问题。