2,5-Dimethoxy-4-(2-propenyl)phenol | 90377-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,5-Dimethoxy-4-(2-propenyl)phenol
• 英文别名: 2,5-dimethoxy-4-prop-2-enylphenol
• CAS: 90377-06-3
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: WPWFNFQROATLTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF<br/>[FR] COMPOSÉS À BASE D'IMIDAZO [1, 2-B] PYRIDAZINE, COMPOSITIONS LES COMPRENANT ET UTILISATIONS DE CEUX-CI
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2013134219A1

  公开（公告）日：2013-09-12

  Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

  基于咪唑并[1,2-b]吡啶嗪的化合物的公式（I）被披露，其中R1、R2和R3在此处被定义。还披露了包含这些化合物的组合物以及它们用于治疗、管理和/或预防由适配器相关激酶1活性介导的疾病和紊乱的方法。
• CATALYTIC SYNTHESIS OF ANTI-UV AND ANTIOXIDANT CONJUGATED 8-8 DIMERS IN A GREEN SOLVENT
  申请人：INSTITUT DES SCIENCES ET INDUSTRIES DU VIVANT ET DE L'ENVIRONNEMENT - AGROPARIS TECH

  公开号：US20220009874A1

  公开（公告）日：2022-01-13

  A process for preparing b-b dimers having anti-UV and antioxidant properties, from p-hydroxycinnamic esters and amides disubstituted in the ortho position with respect to the phenol function and from ketones disubstituted in the ortho position with respect to the phenol, in particular, from sinapic acid esters and amides and ketone analogs. The dimers of formulae (I), (II), (III) and (IV) as obtained by means of the process according to the present disclosure can be used for the production of polymers/plastics (in plastics technology), or for the protection of plants against the cold and as cosmetic or food-processing ingredients, for example. The process may be used to form biobased anti-UV molecules.

  一种制备具有抗紫外线和抗氧化性能的b-b二聚体的方法，该方法使用对酚功能与p-羟基肉桂酸酯和酰胺二取代物以及酮二取代物在邻位上的材料，特别是从芥酸酸酯和酰胺以及酮类类似物中获得。通过本公开的方法获得的式（I）、（II）、（III）和（IV）的二聚体可以用于生产聚合物/塑料（在塑料技术中），或用于保护植物免受寒冷的侵害，并作为化妆品或食品加工成分等。该方法可用于形成生物基抗紫外线分子。
• IGF-1 superagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0742228A1

  公开（公告）日：1996-11-13

  The instant invention provides two-chain IGF-1 superagonists which are derivatives of the naturally occurring single-chain IGF-1 having an abbreviated C domain. The invention also provides synthetic and semi-synthetic DNA sequences, recombinant DNA vectors and transformed host cells useful in the recombinant production of these analogs. The invention also provides pharmaceutical formulations comprising these IGF-1 analogs. The invention also provides methods of using these analogs in a variety of therapeutic applications. The instant invention provides IGF-1 analogs of the formula:         BCn,A   (1) wherein: B is the B domain of IGF-1 or a functional analog thereof, C is the C domain of IGF-1 or a functional analog thereof, n is the number of amino acids in the C domain and is from about 6 to about 12, and A is the A domain of IGF-1 or a functional analog thereof.

  本发明提供了双链 IGF-1 超拮抗剂，它们是天然存在的单链 IGF-1 的衍生物，具有简略的 C 结构域。本发明还提供了用于重组生产这些类似物的合成和半合成 DNA 序列、重组 DNA 载体和转化宿主细胞。本发明还提供了包含这些 IGF-1 类似物的药物制剂。本发明还提供了在各种治疗应用中使用这些类似物的方法。 本发明提供了式IGF-1类似物： BCn,A (1) 其中 B 是 IGF-1 的 B 结构域或其功能类似物、 C 是 IGF-1 的 C 结构域或其功能类似物、 n 是 C 结构域中的氨基酸数目，约为 6 至 12，以及 A 是 IGF-1 的 A 结构域或其功能类似物。
• Neuroprotective synergy of erythropoietin and insulin-like growth factors
  申请人：Digicaylioglu Murat

  公开号：US20050197284A9

  公开（公告）日：2005-09-08

  The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuroprotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a dose of at most 2000 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing neuroprotection and preventing or reducing the severity of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathic pain, migraine, glaucoma, drug addiction, drug withdrawal, drug dependency, depression or anxiety.

  本发明提供了一种提供急性神经保护的方法，该方法通过在接近兴奋性损伤时或之后在神经元细胞中诱导促红细胞生成素（EPO）信号通路；以及在接近兴奋性损伤时或之后在神经元细胞中诱导胰岛素样生长因子（IGF）信号通路，从而在神经元细胞中产生协同的急性神经保护效应。本发明还提供了一种预防或减轻受试者神经系统疾病严重程度的方法，即给受试者注射 EPO 或其活性片段或类似物，剂量不超过 2000 U/kg；同时给受试者注射 IGF 或其活性片段或类似物，从而提供神经保护并预防或减轻神经系统疾病的严重程度。这种方法可用于预防或减轻阿尔茨海默病、帕金森病、亨廷顿病、癫痫、肌萎缩侧索硬化症、多发性硬化症、运动障碍、HIV相关性痴呆、HIV相关性神经病、神经性疼痛、偏头痛、青光眼、药物成瘾、药物戒断、药物依赖、抑郁或焦虑等疾病的严重程度。
• Coating compositions for use in golf balls
  申请人：Hogge F. Matthew

  公开号：US20060089419A1

  公开（公告）日：2006-04-27

  A golf ball comprising a core, a cover encasing the core, at least one coating layer encasing the cover, and at least one indicia layer immediate adjacent to the coating layer is provided. At least one of the indicia and coating layers comprises at least one two-part, reactive composition comprising at least one radiation-curable iso(thio)cyanate and at least one isocyanate-reactive chemical.

  一种高尔夫球包括一个球芯、一个包裹球芯的盖子、至少一个包裹盖子的涂层和至少一个紧邻涂层的指示层。指示层和涂层中至少有一层包含至少一种双组分反应性组合物，该组合物由至少一种辐射固化异（硫）氰酸酯和至少一种异氰酸酯反应性化学品组成。