Tert-butyl 4-(1-benzothiophen-5-yl)-4-hydroxy-2-methylpiperidine-1-carboxylate | 346592-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Tert-butyl 4-(1-benzothiophen-5-yl)-4-hydroxy-2-methylpiperidine-1-carboxylate
• CAS: 346592-91-4
• 化学式: C₁₉H₂₅NO₃S
• 分子量: 347.478
• InChiKey: JUKCYTRCTACOGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-(1-benzothiophen-5-yl)-4-hydroxy-2-methylpiperidine-1-carboxylate 在 silica gel 、 钯 、 polyethylenimine 氢气 、 对甲苯磺酸 作用下， 以 甲醇 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

  摘要：

  A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.088
• 作为产物：
  描述：

  5-溴苯并[b]噻吩 、 1-叔丁氧羰基-2-甲基-哌啶酮 在 1,1-二溴乙烷 、 magnesium 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 Tert-butyl 4-(1-benzothiophen-5-yl)-4-hydroxy-2-methylpiperidine-1-carboxylate
  参考文献：
  名称：

  Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

  摘要：

  A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.088

文献信息

• Indole derivatives for the treatment of depression and anxiety
  申请人：——

  公开号：US20040006229A1

  公开（公告）日：2004-01-08

  The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. 1

  本发明提供了以下化合物的公式（I）：这些化合物对治疗抑郁症、焦虑症，并缓解因戒烟或部分戒烟引起的症状非常有用。
• [EN] INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY<br/>[FR] DERIVES DE L'INDOLE DESTINES AU TRAITEMENT DE DEPRESSION ET D'ANXIETE
  申请人：LILLY CO ELI

  公开号：WO2001046181A1

  公开（公告）日：2001-06-28

  The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

  本发明提供了式(I)的化合物，该化合物对于治疗抑郁症、焦虑症以及减轻戒烟或尼古丁部分戒断引起的症状是有用的。
• INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY
  申请人：ELI LILLY AND COMPANY

  公开号：EP1242411B1

  公开（公告）日：2006-03-08
• US7144898B2
  申请人：——

  公开号：US7144898B2

  公开（公告）日：2006-12-05
• Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4
  作者：Vincent P. Rocco、Patrick G. Spinazze、Todd J. Kohn、Nicholas A. Honigschmidt、David L. Nelson、D. Bradley Wainscott、Laura J. Ahmad、Janice Shaw、Penny G. Threlkeld、David T. Wong、Kumiko Takeuchi

  DOI：10.1016/j.bmcl.2004.02.088

  日期：2004.5

  A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring. (C) 2004 Elsevier Ltd. All rights reserved.