3-Pentadec-10-enylbrenzcatechin | 492-90-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-Pentadec-10-enylbrenzcatechin
• 英文别名: 3-pentadec-10-enylbenzene-1,2-diol
• CAS: 492-90-0
• 化学式: C₂₁H₃₄O₂
• 分子量: 318.5
• InChiKey: WXZPKABXYFJVLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULES FOR IMMUNOGENIC TREATMENT OF CANCER<br/>[FR] PETITES MOLÉCULES POUR LE TRAITEMENT IMMUNOGÈNE DU CANCER
  申请人：CAPTEN THERAPEUTICS INC

  公开号：WO2017180769A1

  公开（公告）日：2017-10-19

  The present invention relates to new compounds for immunogenic treatment of cancer. The compounds can be administered as a single agent or in combination with an anticancer drug including modulators of other immune pathways, especially immune checkpoint inhibitors that target CTLA-4, PD-1, and PD-L1 proteins. The compounds can produce neoantigens through irreversible protein binding in cancer cells and generate immune response.