3-Oxo-22-hydroxybisnor-4-cholen

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-Oxo-22-hydroxybisnor-4-cholen
• 英文别名: 22-Hydroxy-bisnor-20β-chol-4-en-3-on；(8S,9S,10R,13S,14S,17R)-17-[(S)-1-hydroxy-2-propyl]-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one；17-(1-hydroxypropan-2-yl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₂H₃₄O₂
• 分子量: 330.511
• InChiKey: ZNWOYQVXPIEQRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHODS FOR STEREOSELECTIVE REDUCTION<br/>[FR] PROCÉDÉS DE RÉDUCTION STÉRÉOSÉLECTIVE
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2009086451A1

  公开（公告）日：2009-07-09

  The invention is directed to a method to reduce a C-C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.

  本发明涉及一种方法，用于还原类固醇化合物的烯酮的C-C双键，以产生β酮产物和α酮产物的混合物，包括在催化剂和取代吡啶的存在下，用氢气处理类固醇化合物在溶剂中的溶液或悬浮液。
• METHODS FOR STEREOSELECTIVE REDUCTION OF CYCLOPAMINE 4-EN-3-ONE DERIVATIVE
  申请人：Infinity Pharmaceuticals, Inc.

  公开号：EP3190121A1

  公开（公告）日：2017-07-12

  The invention is directed to a method to reduce a C-C double bond of an enone of a steroidal compound to produce a mixture of beta ketone product and alpha ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and substituted pyridine.

  本发明涉及一种还原甾体化合物烯酮的 C-C 双键以生成β酮产物和α酮产物混合物的方法，包括在催化剂和取代的吡啶存在下，用氢气处理该甾体化合物在溶剂中的溶液或悬浮液。
• METHODS FOR STEREOSELECTIVE REDUCTION
  申请人：Austad Brian C.

  公开号：US20110009442A1

  公开（公告）日：2011-01-13

  The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.
• US8716479B2
  申请人：——

  公开号：US8716479B2

  公开（公告）日：2014-05-06
• US9238672B2
  申请人：——

  公开号：US9238672B2

  公开（公告）日：2016-01-19