Oestra-1,3,5(10)-trien-3,15β,16β,17β-tetrol | 58001-91-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Oestra-1,3,5(10)-trien-3,15β,16β,17β-tetrol
• 英文别名: 1,3,5(10)-Estratriene-3,15beta,16beta,17beta-tetrol；(8R,9S,13S,14S,15S,16S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
• CAS: 58001-91-5
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.386
• InChiKey: AJIPIJNNOJSSQC-VKXCEXFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Use of estrogen compounds to increase libido in women
  申请人：——

  公开号：US20040186086A1

  公开（公告）日：2004-09-23

  Disclosed is a method of increasing libido in a woman, said method comprising administering to said woman an effective amount of an estrogenic component selected from the group consisting of: substances represented by the following formula (I) in which formula R 1 , R 2 , R 3 , R 4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.

  本发明公开了一种提高女性性欲的方法，所述方法包括向所述女性施用有效量的雌激素成分，所述雌激素成分选自以下组成的组：由下式（I）代表的物质，其中式 R 1 , R 2 , R 3 , R 4 分别为氢原子、羟基或含有 1-5 个碳原子的烷氧基；每个 R 5 , R 6 , R 7 是羟基；R 1 , R 2 , R 3 , R 4 是氢原子；前体在本方法中使用时能释放出上述式中的物质；以及一种或多种上述物质和/或前体的混合物。
• Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein
  申请人：Bunschoten Johannes Evert

  公开号：US20050261209A1

  公开（公告）日：2005-11-24

  A method of treating or preventing an immune mediated disorder in a mammal, said method comprising the administration of a therapeutically effective amount of an estrogenic component to said mammal, wherein the estrogenic component is selected from the group consisting of: substances represented by the following formula: in which formula R 1 , R 2 , R 3 , R 4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. Another aspect of the invention relates to a pharmaceutical formulation comprising the aforementioned estrogenic component, an immunotherapeutic agent and a pharmaceutically acceptable excipient.

  一种治疗或预防哺乳动物免疫介导紊乱的方法，所述方法包括向所述哺乳动物施用治疗有效量的雌激素成分，其中所述雌激素成分选自由下式所代表的物质组成的组： 式中 R 1 , R 2 , R 3 , R 4 分别为氢原子、羟基或含有 1-5 个碳原子的烷氧基；每个 R 5 , R 6 , R 7 是羟基；R 1 , R 2 , R 3 , R 4 是氢原子；前体在本方法中使用时能够释放出符合上述式子的物质；以及一种或多种上述物质和/或前体的混合物。本发明的另一方面涉及一种药物制剂，其中包括上述雌激素成分、一种免疫治疗剂和一种药学上可接受的赋形剂。
• Method of treating human skin and a skin care composition for use in such a method
  申请人：Coelingh Bennink Jan Tijimen Herman

  公开号：US20050215538A1

  公开（公告）日：2005-09-29

  A cosmetic method of treating human skin by delivering an estrogenic component to said skin, the method comprising applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula in which formula R 1 , R 2 , R 3 , R 4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Another aspect relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.
• Method Of Treating Human Skin And A Skin Care Composition For Use In Such A Method
  申请人：Coelingh Bennink Herman Jan Tijmen

  公开号：US20110160173A1

  公开（公告）日：2011-06-30

  One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R 1 , R 2 , R 3 , R 4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Yet another aspect of the invention relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.
• ESTROGENIC COMPONENTS FOR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：UNIVERSITY DE LIEGE

  公开号：US20150133419A1

  公开（公告）日：2015-05-14

  The invention relates to the prophylactic and therapeutic applications of certain estrogenic components, such as estetrol, in neurological disorders, such as neonatal hypoxic-ischemic encephalopathy (HIE).