(E)-4,4-dimethyl-N-prop-2-enoxypentan-2-imine | 1225571-95-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-4,4-dimethyl-N-prop-2-enoxypentan-2-imine
• CAS: 1225571-95-8
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: RHXXRFBFCLRPQO-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,4-二甲基-2-戊酮 、 O-烯丙基羟胺盐酸盐 在 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 24.58h， 生成 (Z)-4,4-dimethyl-N-prop-2-enoxypentan-2-imine 、 (E)-4,4-dimethyl-N-prop-2-enoxypentan-2-imine
  参考文献：
  名称：

  碳-碳键形成和吡咯的合成通过[3,3]的σ重排ø -乙烯基的肟醚

  摘要：

  描述了一种新的方法，该方法由市售的酮和烯丙基羟胺分两步或三步合成2,4-和2,3,4-取代的吡咯。已开发出铱催化的异构化反应，可将O-烯丙基肟转化为O-乙烯基肟，然后将其进行简便的[3,3]重排以形成1,4-亚氨基醛Paal-Knorr中间体，然后环化生成相应的吡咯。讨论了异构化和吡咯形成的优化方法和实例。

  DOI：

  10.1021/ol100659q

文献信息

• Low Calcemic, Highly Antiproliferative, Analogs of Calcitriol
  申请人：Posner Gary H.

  公开号：US20100137262A1

  公开（公告）日：2010-06-03

  The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.
• LOW CALCEMIC, HIGHLY ANTIPROLIFERATIVE, ANALOGS OF CALCITRIOL
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20170114013A1

  公开（公告）日：2017-04-27

  The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.
• US9481646B2
  申请人：——

  公开号：US9481646B2

  公开（公告）日：2016-11-01
• Carbon−Carbon Bond Formation and Pyrrole Synthesis via the [3,3] Sigmatropic Rearrangement of <i>O</i>-Vinyl Oxime Ethers
  作者：Heng-Yen Wang、Daniel S. Mueller、Rachna M. Sachwani、Hannah N. Londino、Laura L. Anderson

  DOI：10.1021/ol100659q

  日期：2010.5.21

  A new method for the synthesis of 2,4- and 2,3,4-substituted pyrroles in two or three steps from commercially available ketones and allyl hydroxylamine is described. An iridium-catalyzed isomerization reaction has been developed to convert O-allyl oximes to O-vinyl oximes, which undergo a facile [3,3] rearrangement to form 1,4-imino aldehyde Paal−Knorr intermediates that cyclize to afford the corresponding

  描述了一种新的方法，该方法由市售的酮和烯丙基羟胺分两步或三步合成2,4-和2,3,4-取代的吡咯。已开发出铱催化的异构化反应，可将O-烯丙基肟转化为O-乙烯基肟，然后将其进行简便的[3,3]重排以形成1,4-亚氨基醛Paal-Knorr中间体，然后环化生成相应的吡咯。讨论了异构化和吡咯形成的优化方法和实例。