3.5-Dimethyl-2-carbomethoxythiophen | 57041-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3.5-Dimethyl-2-carbomethoxythiophen
• 英文别名: 3,5-Dimethyl-thiophen-2-carbonsaeure-methylester；methyl 3,5-dimethyl-2-thiophenecarboxylate；methyl 3,5-dimethylthiophene-2-carboxylate；3,5-dimethyl-thiophene-2-carboxylic acid methyl ester
• CAS: 57041-28-8
• 化学式: C₈H₁₀O₂S
• 分子量: 170.232
• InChiKey: ATJHYKAQHBXBHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3.5-Dimethyl-2-carbomethoxythiophen 在 乙酸酐 作用下， 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 溶剂黄146 为溶剂， 生成 methyl 3,5-dimethyl-4-nitrothiophene-2-carboxylate
  参考文献：
  名称：

  Herbicidal N-thienyl-chloroacetamides

  摘要：

  该发明提供了式I ArN(Y)COCH.sub.2 Cl I的5-成员杂芳化合物，其中Ar是一个由1个或2个来自O、S和N的杂原子组成的5-成员杂芳基团，并且通过一个环C原子连接到N原子的N(Y)COCH.sub.2 Cl基团，Ar为吡唑基时，所述的N(Y)COCH.sub.2 Cl基团处于4-位置，Y如描述中所述，这些化合物的用途包括除草剂，促进此类用途的组合物以及氯乙酰胺的制备。

  公开号：

  US04666502A1
• 作为产物：
  描述：

  4-chloropent-3-en-2-one 、 巯基乙酸甲酯 、 sodium ethanolate 在 水 、 二氯甲烷 、 Sodium sulfate-III 、 silica gel 、 乙酸乙酯 、 A 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以to give a mixture (8.1 g, 1:1 by 1H-NMR) of A (3,5-dimethyl-thiophene-2-carboxylic acid ethyl ester) and B (3,5-dimethyl-thiophene-2-carboxylic acid methyl ester)的产率得到3.5-Dimethyl-2-carbomethoxythiophen
  参考文献：
  名称：

  Heterocyclic Carboxamide Compounds as Steroid Nuclear Receptors Ligands

  摘要：

  本文介绍了杂环羧酰胺化合物作为调节类固醇核受体活性的有用物质。还描述了含有这些化合物的制药组合物，使用这些化合物的方法以及制造这些化合物的过程。

  公开号：

  US20110144128A1

文献信息

• Thiophene-carboxamides useful as inhibitors of protein kinases
  申请人：Brenchley Guy

  公开号：US20070219205A1

  公开（公告）日：2007-09-20

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病、病况或疾患的方法。本发明还提供了制备发明化合物的方法。
• Thiophene azo dyes and laundry care compositions containing the same
  申请人：The Procter & Gamble Company

  公开号：US10435651B2

  公开（公告）日：2019-10-08

  This application relates to thiophene azo dyes for use as hueing agents, laundry care compositions comprising such thiophene azo dyes, processes for making such thiophene azo dyes, and laundry care compositions and methods of using the same. The thiophene azo dyes contain a formally charged moiety and are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. These thiophene azo dyes are advantageous in providing a hueing effect, for example, a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. The thiophene azo dyes are also generally stable to bleaching agents used in laundry care compositions.

  本申请涉及用作着色剂的噻吩偶氮染料、含有此类噻吩偶氮染料的衣物护理组合物、制造此类噻吩偶氮染料的工艺以及衣物护理组合物和使用方法。噻吩偶氮染料含有正式带电分子，通常由至少两种成分组成：至少一种发色团成分和至少一种聚合物成分。合适的发色团成分在紫外线照射下一般会发出蓝色、红色、紫色或紫罗兰色的荧光，也可以吸收光来反射这些相同的色调。这些噻吩偶氮染料在提供色调效果（例如，织物的增白效果）方面具有优势，同时不会随着时间的推移而积累，导致处理过的织物出现不希望看到的蓝色褪色。噻吩偶氮染料对洗衣护理组合物中使用的漂白剂通常也很稳定。
• HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS
  申请人：Exelixis, Inc.

  公开号：EP1844020A1

  公开（公告）日：2007-10-17
• THIOPHENE AZO DYES AND LAUNDRY CARE COMPOSITIONS CONTAINING THE SAME
  申请人：The Procter & Gamble Company

  公开号：US20180066215A1

  公开（公告）日：2018-03-08

  This application relates to thiophene azo dyes for use as hueing agents, laundry care compositions comprising such thiophene azo dyes, processes for making such thiophene azo dyes, and laundry care compositions and methods of using the same. The thiophene azo dyes contain a formally charged moiety and are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. These thiophene azo dyes are advantageous in providing a hueing effect, for example, a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. The thiophene azo dyes are also generally stable to bleaching agents used in laundry care compositions.
• US3948633A
  申请人：——

  公开号：US3948633A

  公开（公告）日：1976-04-06