calcium 5-methyltetrahydrofolate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: calcium 5-methyltetrahydrofolate
• 英文别名: calcium salt of 5-methyltetrahydrofolic acid；Calcium 2-(4-(((2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioate；calcium;2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
• 化学式: C₂₀H₂₃N₇O₆*Ca
• 分子量: 497.524
• InChiKey: VWBBRFHSPXRJQD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.31
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  204
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  5-Methyl-tetrahydrofolsaeure 、 calcium 5-methyltetrahydrofolate 、 sodium sulfate 以 水 为溶剂， 生成 sodium-N(5)-methyl-5,6,7,8-tetrahydrofolic acid
  参考文献：
  名称：

  Process for producing d,1-5-methyltetrahydrofolic acid and its salts

  摘要：

  一种制备d,1-5-甲基四氢叶酸及其盐的方法，其化学式为：##STR1## 其中X为氢、碱金属或碱土金属；通过用硼氢化钠还原叶酸，然后在惰性气氛中用甲醛和硼氢化钠的水溶液对所得到的四氢叶酸进行甲基化。

  公开号：

  US05124452A1
• 作为产物：
  描述：

  2-[[4-(3-amino-1-oxo-5,6,6a,7-tetrahydro-2H-imidazo[1,5-f]pteridin-10-ium-8-yl)benzoyl]amino]pentanedioic acid;chloride;hydrochloride 生成 calcium 5-methyltetrahydrofolate
  参考文献：
  名称：

  CONTI, J.;MUELLER, H. -R.

  摘要：

  DOI：

文献信息

• [EN] FOLATES, COMPOSITIONS AND USES THEREOF<br/>[FR] FOLATES, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：GNOSIS SPA

  公开号：WO2009103334A1

  公开（公告）日：2009-08-27

  The present invention relates to folates, compositions and uses thereof; In particular, this invention describes a crystalline or amorphous compound which is a substituted or unsubstituted folate or a reduced folate, or the natural or unnatural isomers thereof, of at least one organic base, as well as compositions and uses thereof. The compounds of the invention show a long lasting stability as well as a peculiarly high water-solubility.

  本发明涉及叶酸、其组合物和用途；具体而言，本发明描述了一种晶体或非晶体化合物，该化合物是一种取代或未取代的叶酸或还原叶酸，或其天然或非天然异构体，至少含有一种有机碱基，以及其组合物和用途。本发明的化合物表现出长期稳定性以及特别高的水溶性。
• COMPOSITION OF (6S)-5-METHYL TETRAHYDROFOLIC ACID OR SALT THEREOF AS WELL AS PREPARATION THEREFOR AND APPLICATION THEREOF
  申请人：Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd.

  公开号：EP3190112A1

  公开（公告）日：2017-07-12

  Disclosed are a composition comprising (6S)-5-methyl tetrahydrofolic acid or a salt thereof, and preparation and use thereof. In the composition, the content of (6S)-5-methyl tetrahydrofolic acid or the salt thereof is not less than 98.0%, the content of a related impurity JK12A is not greater than 0.1%, and 5-methyl tetrahydropterioic acid is not detectable.

  本发明公开了一种包含(6S)-5-甲基四氢叶酸或其盐的组合物及其制备和使用方法。在该组合物中，(6S)-5-甲基四氢叶酸或其盐的含量不低于 98.0%，相关杂质 JK12A 的含量不高于 0.1%，且检测不到 5-甲基四氢蝶酸。
• Solid solution comprising (6S)-5-methyl tetrahydrofolic acid or salt thereof, and preparation and use thereof
  申请人：LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO., LTD.

  公开号：US10398697B2

  公开（公告）日：2019-09-03

  Disclosed are a composition including (6S)-5-methyl tetrahydrofolic acid or a salt thereof, and preparation and use thereof. In the composition, the content of (6S)-5-methyl tetrahydrofolic acid or the salt thereof is not less than 98.0%, the content of a related impurity JK12A is not greater than 0.1%, and 5-methyl tetrahydropterioic acid is not detectable.

  本发明公开了一种包括(6S)-5-甲基四氢叶酸或其盐的组合物及其制备和使用方法。在该组合物中，(6S)-5-甲基四氢叶酸或其盐的含量不低于 98.0%，相关杂质 JK12A 的含量不高于 0.1%，且检测不到 5-甲基四氢蝶酸。
• Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least S-adenosyl-L-methionine salt.
  申请人：KNOLL FARMACEUTICI S.p.a.

  公开号：EP0482493B1

  公开（公告）日：2001-02-28
• NATURAL FORMULATION FOR THE TREATMENT AND PREVENTION OF DEPRESSION, CONTAINING ST JOHN'S WORT AND DERIVATIVES OF DIHYDRO- AND TETRAHYDROFOLIC ACID
  申请人：MERCK PATENT GmbH

  公开号：EP1121139A1

  公开（公告）日：2001-08-08