2,3-Diheptylnaphthalene-1,4-dione | 1426962-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-Diheptylnaphthalene-1,4-dione
• 英文别名: 2,3-diheptylnaphthalene-1,4-dione
• CAS: 1426962-00-6
• 化学式: C₂₄H₃₄O₂
• 分子量: 354.533
• InChiKey: UNUGNYHOSJTXGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  辛酸 、 1,4-萘醌 在 ammonium peroxydisulfate 、 silver nitrate 作用下， 以 水 、 乙腈 为溶剂， 以40%的产率得到2,3-Diheptylnaphthalene-1,4-dione
  参考文献：
  名称：

  Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones

  摘要：

  The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Tiypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T cruzi, especially 24((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC50 of 7.8 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.11.034

文献信息

• Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones
  作者：Adriano Olímpio da Silva、Rosangela da Silva Lopes、Ricardo Vieira de Lima、Camila Santos Suniga Tozatti、Maria Rita Marques、Sérgio de Albuquerque、Adilson Beatriz、Dênis Pires de Lima

  DOI：10.1016/j.ejmech.2012.11.034

  日期：2013.2

  The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Tiypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T cruzi, especially 24((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC50 of 7.8 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.