4-Propyl-pyrogallol | 46034-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Propyl-pyrogallol
• 英文别名: 1,2,3-Trihydroxy-4-propyl-benzol；2.3.4-Trihydroxy-1-propyl-benzol；4-Propylbenzene-1,2,3-triol
• CAS: 46034-82-6
• 化学式: C₉H₁₂O₃
• 分子量: 168.192
• InChiKey: UYXNRGBCOOUFRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Propyl-pyrogallol 在 potassium iodate 作用下， 生成 Di-n-propyl-4',7-purpurogallin
  参考文献：
  名称：

  某些邻苯三酚和紫杉醇衍生物的氧化

  摘要：

  讨论了许多4-和5-单取代和4,6-二取代的邻苯三酚的氧化产物。4-烷基邻苯三酚产生相应的4'，7-二烷基紫杉醇，并阐明了由这些化合物与碱性过氧化氢进一步氧化而得的产物的结构。5-单和4,6-二烷基邻苯三酚衍生物的氧化分别产生特征性的白色和黄色二聚体。证据表明，前者为三环十二烷，后者为二苯并二恶英结构。描述了在用碱处理时，二苯并二恶英二聚体向苯并环戊二恶英异构体的转化。

  DOI：

  10.1016/0040-4020(67)85149-4
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 amalgamated zinc 作用下， 生成 4-Propyl-pyrogallol
  参考文献：
  名称：

  Alkyl Phenols. I. The 4-n-Alkylpyrogallols¹

  摘要：

  DOI：

  10.1021/ja01301a036

文献信息

• [EN] METHOD FOR THE DEACYLATION AND/OR DEALKYLATION OF COMPOUNDS<br/>[FR] PROCÉDÉ DE DÉSACYLATION ET/OU DE DÉSALKYLATION DE COMPOSÉS
  申请人：UNIV ANTWERPEN

  公开号：WO2019025535A1

  公开（公告）日：2019-02-07

  The present invention in general relates to a method for the deacylation and/or dealkylation (both O-dealkylation as well as C-dealkylation) of compounds, more specifically of aromatic compounds. The method is characterized by contacting the compound with an acid-containing aqueous reaction mixture using high temperature and high pressure conditions. The invention also provides a method for preparing a compound suitable for further deacylation using the method of the invention.

  本发明总体上涉及一种去酰化及/或脱烷基化（包括O-脱烷基化和C-脱烷基化）化合物的方法，更具体地说是芳香族化合物的方法。该方法的特点是在高温高压条件下，将化合物与含有酸的水性反应混合物接触。发明还提供了一种使用本发明方法进一步去酰化的合适化合物的制备方法。
• [EN] COMPOSITIONS AND METHODS FOR TREATING CANCER<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DU CANCER
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2019040647A1

  公开（公告）日：2019-02-28

  Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in the subject.

  本文提供了用于治疗、抑制和/或减轻神经母细胞瘤、小细胞肺癌（SCLC）、大细胞神经内分泌癌（LCNEC）、大细胞癌（LCC）、鳞状细胞癌（SqCC）和/或腺癌（AC）的组合物和方法，适用于需要的受试者。该方法包括提供抑制ONECUT2表达或活性的药剂，并向受试者施用治疗有效量的药剂，以治疗、抑制和/或减轻神经母细胞瘤、小细胞肺癌（SCLC）、大细胞神经内分泌癌（LCNEC）、大细胞癌（LCC）、鳞状细胞癌（SqCC）和/或腺癌（AC）。
• STABILIZATION OF HOUSEHOLD, BODY-CARE AND FOOD PRODUCTS BY USING BENZOTROPOLONE CONTAINING PLANT EXTRACTS AND/OR RELATED BENZOTROPOLONE DERIVATIVES
  申请人：Wagner Barbara

  公开号：US20120230925A1

  公开（公告）日：2012-09-13

  Disclosed is the use of benzotropolone derivatives of formula (1), wherein R 1 , R 2 and R 7 independently from each other are hydrogen; C 1 -C 3 alkyl; or COR 8 ; R 3 is hydrogen; or COOR 9 R 4 is hydrogen; or C 1 -C 3 alkyl; R 5 is hydrogen; hydroxy; C 1 -C 3 -alkoxy; or -0-(CO)—R 10 ; R 6 is hydrogen; C 1 -C 3 alkyl; or COR 8 ; or R 5 and R 6 together may form a five or six membered ring; or R 6 and R 7 together form a five or six membered ring; and R 8 , R 9 , R 10 independently of each other are C 1 -C 30 alkyl; for protecting body-care and household products from photolytic and oxidative degradation.

  本发明涉及一种使用化学式（1）中的苯并三酮衍生物的方法，其中R1、R2和R7分别独立地为氢原子；C1-C3烷基；或COR8；R3为氢原子；或COOR9；R4为氢原子；或C1-C3烷基；R5为氢原子；羟基；C1-C3-烷氧基；或-0-(CO)—R10；R6为氢原子；C1-C3烷基；或COR8；或R5和R6可以共同形成五元或六元环；或R6和R7可以共同形成五元或六元环；且R8、R9、R10分别独立地为C1-C30烷基；用于保护身体护理和家用产品免受光解和氧化降解的方法。
• Radiation-sensitive resin composition
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0365318A2

  公开（公告）日：1990-04-25

  A radiation-sensitive resin composition comprising an alkali-soluble novolak resin and a 1,2-quinonediazide compound, wherein the alkali-soluble novolak resin comprises a mixture of: 95-50 parts by weight of Resin A having a standard polystyrene-reduced weight-average molecular weight of 4,000-20,000 [Resin A is at least one resin selected from the group consisting of a resin obtained by polycondensation of m-cresol and at least one phenol represented by the structural formula (I) or (I′): wherein m is 2 or 3, with at least one aldehyde and a resin obtained by polycondensation of m-cresol, p-cresol and at least one phenol repreented by the above structural formula (I) or (I′) with at least one aldehyde] and 5-50 parts by weight of Resin B having a standard polystyrene-reduced weight-average molecular weight of 200-2,000 [Resin B is a resin obtained by polycondensation of at least one phenol represented by the structural formula (II): wherein n is 0, 1, 2 or 3, with at least one aldehyde]. In the resin composition, the mixture of Resin A and Resin B may further contain Resin C which is an ester of Resin B with a 1,2-quinonediazidesulfonic acid. The radiation-­sensitive resin compopsition is suitable for use as a positive type resist having high sensitivity, excellent developability, high resolution and excellent heat resistance.

  一种辐射敏感树脂组合物，包括碱溶性酚醛树脂和 1，2-醌噻嗪化合物，其中碱溶性酚醛树脂包括以下物质的混合物： 95-50 重量份的树脂 A，其标准聚苯乙烯还原平均分子量为 4,000-20,000 [树脂 A 是至少一种树脂，选自由间甲酚和至少一种由结构式(I)或(I′)代表的苯酚缩聚而成的树脂： 其中 m 为 2 或 3，与至少一种醛缩聚而得的树脂，以及间甲酚、对甲酚和由上述结构式 (I) 或 (I′) 表示的至少一种苯酚与至少一种醛缩聚而得的树脂]和 5-50 份（重量）标准聚苯乙烯还原平均分子量为 200-2,000 的树脂 B [树脂 B 是由至少一种结构式（II）所代表的苯酚缩聚而成的树脂： 其中 n 为 0、1、2 或 3，与至少一种醛缩聚而成的树脂]。 在树脂组合物中，树脂 A 和树脂 B 的混合物可进一步包含树脂 C，它是树脂 B 与 1,2-醌二磺酸的酯。辐射敏感树脂组合物适合用作正型抗蚀剂，具有高灵敏度、优异的显影性、高分辨率和优异的耐热性。
• Curing agent for epoxy resin
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0424872A2

  公开（公告）日：1991-05-02

  A curing agent for an epoxy resin comprising (A) a polyhydric phenol obtainable by condensing a phenol compound and a hydroxybenzaldehyde and (B) a dihydric phenol, which gives a cured material of an epoxy resin having improved moisture and heat resistance and a small coefficient of linear thermal expansion.

  一种环氧树脂固化剂，由 (A) 通过缩合苯酚化合物和羟基苯甲醛得到的多氢苯酚和 (B) 二氢苯酚组成，该固化剂可得到具有更好的防潮和耐热性能以及较小的线性热膨胀系数的环氧树脂固化物。