The Synthesis of 3,5-Diamino-1,2,4-oxadiazoles. 1st Communication
作者:Jefferson W. Tilley、Henri Ramuz
DOI:10.1002/hlca.19800630411
日期:1980.6.6
Reaction of the 1-substituted-3-cyano-isothioureas 6 with hydroxylamine gave mixtures of the 5-amino-3-substituted-amino-1,2,4-oxadiazoles 1 and the isomeric 3-amino-5-substituted-amino-1,2,4-oxadiazoles 8 in which 1 usually predominated. The structural assignment of these products is discussed. In a second method, the 2-hydroxy-1-methyl-1-phenyl-guanidine 15 was converted to the corresponding 3-d
MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF
申请人:Ahrendt Kateri
公开号:US20100041719A1
公开(公告)日:2010-02-18
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment of various disorders.
MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF
申请人:Array BioPharma Inc.
公开号:US20140018399A1
公开(公告)日:2014-01-16
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Mitotic kinesin inhibitors and methods of use thereof
申请人:Hans Jeremy
公开号:US20100331283A1
公开(公告)日:2010-12-30
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.