Naphthalene, 1,2-difluoro-6-(trans-4-propylcyclohexyl)- | 247924-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalene, 1,2-difluoro-6-(trans-4-propylcyclohexyl)-
• 英文别名: 1,2-difluoro-6-(trans-4-propylcyclohexyl)naphthalene；5,6-Difluoro-2-(trans-4-propylcyclohexyl)naphthalene
• CAS: 247924-91-0
• 化学式: C19H22F2
• InChiKey: RRSFREKZTNVCSV-HDJSIYSDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.19
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  Naphthalene, 1,2-difluoro-6-(trans-4-propylcyclohexyl)- 在 正丁基锂 、 N-氟代双苯磺酰胺 作用下， 生成 Naphthalene, 1,2,3-trifluoro-6-(trans-4-propylcyclohexyl)-
  参考文献：
  名称：

  Design, Synthesis and Physical Properties of New Liquid Crystal Materials for Active Matrix LCD (2)

  摘要：

  Novel 1-fluoro- and 1,2-difluoronaphthalene derivatives were designed for active matrix LCD and were prepared through the regioselective fluorination of 6-substituted 2-naphthols. These compounds exhibited high nematic-isotropic transition temperatures with very large dielectric anisotropy and large birefringences. These results are useful for design of new liquid crystal mixtures for TFT-displays.

  DOI：

  10.1080/10587250108025059
• 作为产物：
  描述：

  Naphthalene,1,1,2,2-tetrafluoro-1,2-dihydro-6-(trans-4-propylcyclohexyl)- 在 palladium on activated charcoal 氢气 作用下， 生成 Naphthalene, 1,2-difluoro-6-(trans-4-propylcyclohexyl)-
  参考文献：
  名称：

  Design, Synthesis and Physical Properties of New Liquid Crystal Materials for Active Matrix LCD (2)

  摘要：

  Novel 1-fluoro- and 1,2-difluoronaphthalene derivatives were designed for active matrix LCD and were prepared through the regioselective fluorination of 6-substituted 2-naphthols. These compounds exhibited high nematic-isotropic transition temperatures with very large dielectric anisotropy and large birefringences. These results are useful for design of new liquid crystal mixtures for TFT-displays.

  DOI：

  10.1080/10587250108025059

文献信息

• Synthesis of vicinal difluoro aromatics and intermediates thereof
  申请人：Klauck-Jacobs Axel

  公开号：US06894200B2

  公开（公告）日：2005-05-17

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds using various bases and a method of preparing intermediates thereof. A method for making a vicinal difluoro halogenated aromatic compound including providing a tetrafluoro derivative of a halogen substituted aromatic compound, wherein the tetrafluoro derivative has two fluorine atoms on each of two adjacent carbons and at least one additional halogen substituent; reacting the tetrafluoro derivative with a reducing agent in presence of a base for a reaction time sufficient to form the vicinal difluoro halogenated aromatic compound containing two vicinal fluorine substituents and the at least one additional halogen substituent, wherein the reducing agent is used in a reducing agent effective amount sufficient to retain the at least one additional halogen substituent.

  一种从羟基芳香化合物中使用各种碱制备高产率的邻二氟芳香化合物的方法，以及制备其中间体的方法。一种制备邻二氟卤代芳香化合物的方法，包括提供卤代芳香化合物的四氟衍生物，其中该四氟衍生物在两个相邻碳上各有两个氟原子和至少一个额外的卤素取代基；将四氟衍生物与还原剂在碱的存在下反应，反应时间足以形成含有两个邻位氟取代基和至少一个额外卤素取代基的邻二氟卤代芳香化合物，其中还原剂用于保留至少一个额外卤素取代基的有效量。
• SYNTHESIS OF VICINAL DIFLUORO AROMATICS AND INTERMEDIATES THEREOF
  申请人：——

  公开号：US20020099247A1

  公开（公告）日：2002-07-25

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds and a method of preparing intermediates thereof. The hydroxy aromatic compound can be a mono-, bi- or tricyclic aromatic in which the rings are separate or fused. One or more of the rings can contain heteroatoms, such as oxygen, nitrogen, or sulfur, and can contain one or more substitutions, in addition to the hydroxy substitution.

  从羟基芳香化合物制备高收率的邻二氟芳香化合物的方法以及制备其中间体的方法。羟基芳香化合物可以是一个单环、双环或三环芳香化合物，其中环是分开的或融合的。一个或多个环可以含有杂原子，如氧、氮或硫，并且除了羟基取代外，还可以含有一个或多个取代基。
• Naphthalene derivative and liquid crystal composition comprising the same
  申请人：Dainippon Ink and Chemicals, Inc.

  公开号：US20030136944A1

  公开（公告）日：2003-07-24

  Disclosed in a novel liquid-crystalline compound which is a naphthalene derivative useful as an electro-optical liquid crystal display material, a liquid crystal composition containing such naphthalene derivatives and a liquid crystal display device comprising the same. The naphthalene derivative provided by the present invention exhibits an excellent liquid-crystallinity and miscibility with currently widely used liquid crystal compositions or compositions. The addition of the naphthalene derivative makes it possible to drastically lower the threshold voltage of the liquid crystal composition while maintaining its high response. The naphthalene derivative of the present invention is characterized by a large birefringence index. Further, most of the naphthalene derivative of the present invention has no strongly polar group in its molecule and thus can also be used for active matrix driving. Moreover, as shown in the foregoing examples, the naphthalene derivative of the present invention can be easily produced and is colorless and chemically stable. Accordingly, the liquid crystal composition comprising the naphthalene derivative of the present invention is extremely useful as a practical liquid crystal composition, particularly a liquid crystal composition which can operate within a wide temperature range and requires a high speed response and a low voltage driving.

  本发明揭示了一种新型液晶化合物，该化合物是萘衍生物，可用作电光液晶显示材料，液晶组合物包含这种萘衍生物，以及包含它的液晶显示装置。本发明提供的萘衍生物表现出优异的液晶性和与目前广泛使用的液晶组合物或配方的混溶性。添加萘衍生物可以在保持高响应的同时大幅降低液晶组合物的阈值电压。本发明的萘衍生物具有较大的双折射率指数。此外，大多数本发明的萘衍生物分子中没有强极性基团，因此也可用于有源矩阵驱动。此外，正如前面的例子所示，本发明的萘衍生物可以很容易地制备，无色且化学稳定。因此，包含本发明的萘衍生物的液晶组合物非常有用作为实用的液晶组合物，特别是需要在广泛的温度范围内工作并需要高速响应和低电压驱动的液晶组合物。
• Design, Synthesis and Physical Properties of New Liquid Crystal Materials Having a Fluoro-Substituted Tetrahydronaphthalene Structure for Active Matrix LCD
  作者：Tetsuo Kusumoto、Yoshitaka Saito、Yutaka Nagashima、Makoto Negishi、Sadao Takehara、Yoshinori Iwashita、Kiyofumi Takeuchi、Haruyoshi Takatsu、Corneria Pithart、Rainer Frings、Artur Lachowicz、Gerwald Grahe

  DOI：10.1080/15421400490434973

  日期：2004.1

  Liquid crystal materials having a fluoro-substituted tetralhydro-naphthalene structure were designed for active matrix LCD. 6-Aryl-5-fluoro-1,2,3,4-tetrahydronaphthalenes and 5,6-difluro-1,2,3,4-tetrahydronaphthalenes were prepared by regioselective fluorination and hydrogenation of 2-naphthols. 6-Aryl-5,7-difluoro-1,2,3,4-tetrahydronaphthalenes were synthesized from 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-one. The liquid crystal mixture containing these compounds with very good co-solubility exhibits a wide nematic temperature range with low melting point and very large value of dielectric anisotropy. From these results these compounds are useful for design. of new liquid crystal mixtures for TFT-displays.
• JP2001010995A
  申请人：——

  公开号：JP2001010995A

  公开（公告）日：2001-01-16