phenyl 2-(trimethylsilyl)ethyl phthalate | 1416009-54-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: phenyl 2-(trimethylsilyl)ethyl phthalate
• 英文别名: 2-O-phenyl 1-O-(2-trimethylsilylethyl) benzene-1,2-dicarboxylate
• CAS: 1416009-54-5
• 化学式: C₁₉H₂₂O₄Si
• 分子量: 342.467
• InChiKey: GVUORTFIRCBQDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  phenyl 2-(trimethylsilyl)ethyl phthalate 在 四丁基氟化铵 、 重水 作用下， 以 四氢呋喃 、 氘代二甲亚砜 为溶剂， 反应 4.0h， 生成 邻苯二甲酸 、 苯酚
  参考文献：
  名称：

  Self-Immolative Aryl Phthalate Esters

  摘要：

  We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.

  DOI：

  10.1021/jo301698v
• 作为产物：
  描述：

  苯酐 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 phenyl 2-(trimethylsilyl)ethyl phthalate
  参考文献：
  名称：

  Self-Immolative Aryl Phthalate Esters

  摘要：

  We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.

  DOI：

  10.1021/jo301698v

文献信息

• Self-Immolative Aryl Phthalate Esters
  作者：Kaitlyn M. Mahoney、Pratik P. Goswami、Arthur H. Winter

  DOI：10.1021/jo301698v

  日期：2013.1.18

  We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.