dimethyl(thexyl)silyl chloride | 165460-81-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: dimethyl(thexyl)silyl chloride
• 英文别名: thexyldimethylsilyl chloride；tert-hexyldimethylchlorosilane；t-hexyldimethylsilyl chloride；terthexyldimethylchlorosilane；thexyl(dimethyl)chlorosilane；TDSCl；chloro-dimethyl-(2-methylpentan-2-yl)silane
• CAS: 165460-81-1
• 化学式: C₈H₁₉ClSi
• mdl: MFCD00082927
• 分子量: 178.777
• InChiKey: KAADXUXXXANQKW-UHFFFAOYSA-N

物化性质

• 沸点：
  176.1±9.0 °C(Predicted)
• 密度：
  0.860±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dimethyl(thexyl)silyl chloride 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成 2-{[dimethyl(thexyl)silyl]ethynyl}-1-iodobiphenylene
  参考文献：
  名称：

  (η6-[7]Heliphene)tricarbonylchromium via an Optimized Preparation of [7]Heliphene

  摘要：

  Optimized procedures to [7]heliphene are described that allowed the synthesis of ((6)-[7]heliphene)tricarbonylchromium and a preliminary exploration of its chemical behavior. DFT calculations provide structural and energetic information on this complex and its haptomeric isomers. Attempts to prepare the corresponding ([7]heliphene)chromium sandwich failed so far, but DFT evidence is presented to indicate that the target should be accessible.

  DOI：

  10.1055/s-0034-1380535

文献信息

• Compositions of retinoids substituted with a dithiane ring, their use,
  申请人：L'Oreal

  公开号：US05296505A1

  公开（公告）日：1994-03-22

  The invention relates to a stereospecific derivative of formula: ##STR1## in which R is hydrogen or a C.sub.1 -C.sub.4 thioalkyl. The invention also relates to the use of these compounds for the manufacture of stereospecific retinal or retinoic acid, as well as to a process for preparing the retinoids of formula (I). The invention finally relates to a cosmetic or pharmaceutcial composition which contains at least one compound of formula (I) in a suitable vehicle; the pharmaceutical composition according to the invention may be used for treating dermatological, rheumatic, respiratory or ophthalmological conditions.

  该发明涉及一种具有以下结构的立体特异性衍生物：##STR1##其中R为氢或C.sub.1-C.sub.4硫代烷基。该发明还涉及利用这些化合物制备立体特异性视黄醛或视黄酸，以及制备式(I)的视黄醇的方法。最后，该发明涉及一种化妆品或药用组合物，其中至少含有一种式(I)的化合物在适当的载体中；根据该发明的药用组合物可用于治疗皮肤病、风湿病、呼吸道疾病或眼科疾病。
• Glycosylated prodrugs, their method of preparation and their uses
  申请人：Laboratoires Hoechst

  公开号：US05561119A1

  公开（公告）日：1996-10-01

  Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##

  糖基化前药、其制备方法以及其与肿瘤特异性免疫酶偶联物一起用于治疗癌症的用途被描述。这些蒽环类前药的化学式为(I)。
• Silyl derivatives of eugenol
  申请人：Aristech Chemical Corporation

  公开号：US05110971A1

  公开（公告）日：1992-05-05

  Silyl derivatives of eugenol include compositions of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are independently selected from linear, branched, and cyclic hydrocarbon groups having a total of from one to about eight carbon atoms, except that where one of R.sup.1, R.sup.2 or R.sup.3 is a phenyl group, the total of carbon atoms must be at least nine. They may be made by silylating the corresponding hydroxyl compound. They are useful as comonomers for olefins to introduce functional sites and may be copolymerized in Ziegler-Natta catalyst systems.

  丁香酚的硅基衍生物包括以下式的组合物：其中R.sup.1、R.sup.2和R.sup.3分别从具有总共一到约八个碳原子的线性、支链和环烃基中独立选择，但如果R.sup.1、R.sup.2或R.sup.3中有一个是苯基，则碳原子的总数必须至少为九。它们可以通过硅基化相应的羟基化合物制备。它们可用作烯烃的共聚单体，以引入功能位点，并可在齐格勒-纳塔催化剂体系中共聚。
• EP2781522
  申请人：——

  公开号：——

  公开（公告）日：——
• (η6-[7]Heliphene)tricarbonylchromium via an Optimized Preparation of [7]Heliphene
  作者：K. Vollhardt、Daniel Holmes、Sang Lee、Sabine Lotz、Son Nguyen、Gaston Schaller、Rachel Schmidt-Radde

  DOI：10.1055/s-0034-1380535

  日期：——

  Optimized procedures to [7]heliphene are described that allowed the synthesis of ((6)-[7]heliphene)tricarbonylchromium and a preliminary exploration of its chemical behavior. DFT calculations provide structural and energetic information on this complex and its haptomeric isomers. Attempts to prepare the corresponding ([7]heliphene)chromium sandwich failed so far, but DFT evidence is presented to indicate that the target should be accessible.