2-Amino-2-methylpropane-1,3-diol hydrochloride | 24801-54-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Amino-2-methylpropane-1,3-diol hydrochloride
• 英文别名: 2-amino-2-methylpropan-1,3-diol hydrochloride；2-amino-2-methyl-propane-1,3-diol; hydrochloride；2-Amino-2-methyl-propan-1,3-diol; Hydrochlorid；2-amino-2-methyl-1,3-propanediol hydrochloride；2-Amino-2-methylpropane-1,3-diol;hydrochloride
• CAS: 24801-54-5
• 化学式: C₄H₁₁NO₂*ClH
• 分子量: 141.598
• InChiKey: GZTKYOABNIDNQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.89
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  光气 、 2-Amino-2-methylpropane-1,3-diol hydrochloride 以 甲苯 为溶剂， 反应 7.0h， 以88%的产率得到1,3-bis-3-chloropropionyloxy-2-methylpropane-2-isocyanate
  参考文献：
  名称：

  WO2006/49264

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氨基-2-甲基-1,3-丙二醇 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 2-Amino-2-methylpropane-1,3-diol hydrochloride
  参考文献：
  名称：

  WO2006/49264

  摘要：

  公开号：

文献信息

• AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1961734B1

  公开（公告）日：2011-09-14
• AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2168944B1

  公开（公告）日：2016-05-11
• Chemical Modification and Biological Evaluation of New Semisynthetic Derivatives of 28,29-Didehydronystatin A₁ (S44HP), a Genetically Engineered Antifungal Polyene Macrolide Antibiotic
  作者：Maria N. Preobrazhenskaya、Evgenia N. Olsufyeva、Svetlana E. Solovieva、Anna N. Tevyashova、Marina I. Reznikova、Yuryi N. Luzikov、Larisa P. Terekhova、Aleksei S. Trenin、Olga A. Galatenko、Ivan D. Treshalin、Elena P. Mirchink、Vladimir M. Bukhman、Håvard Sletta、Sergey B. Zotchev

  DOI：10.1021/jm800695k

  日期：2009.1.8

  Twenty-three new derivatives of the heptaene nystatin analogue 28,29-didehydronystatin A(1) (1) (S44HP) were obtained by chemical modification of C 16 carboxyl and amino groups of mycosamine. These derivatives comprised 15 carboxamides, 4 N-alkyl derivatives, 3 N-derivatives containing additional N-linked monosaccharide or disaccharide moiety (products of Amadori rearrangement), and 1 N-aminnoacyl derivative. The derivatives have been tested in vitro against yeasts Candida albicans, Cryptococcus humicolus, and filamentous fungi (molds) Aspergillus niger and Fusarum oxysporum, as well as for hemolytic activity against human erythrocytes. Structure-activity relationships for the compounds obtained are discussed. The most active and least hemolytic derivative 3-(N,N-dimethylamino)propylamide of S44HP (6) was tested for acute toxicity and antifungal activity in animal model. Whereas amphotericin B and S44HP were active in vivo at doses close to the maximal tolerated dose, 6 was considerably less toxic and more active compared to these two antibiotics.
• Jones, Journal of the Association of Official Agricultural Chemists, 1944, vol. 27, p. 468,470
  作者：Jones

  DOI：——

  日期：——
• Crystalline Procaine Penicillins
  作者：Charles J. Salivar、F. Howard Hedger、Ellis V. Brown

  DOI：10.1021/ja01183a518

  日期：1948.3.1