1-[(2R,4R,5S)-4-[[[(2R,3S,5R)-3-[tert-butyl(diphenyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyamino]methyl]-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione | 140676-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[(2R,4R,5S)-4-[[[(2R,3S,5R)-3-[tert-butyl(diphenyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyamino]methyl]-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 140676-15-9
• 化学式: C₅₆H₆₁N₅O₉Si
• 分子量: 976.214
• InChiKey: GETPLHYZPLRAFJ-GCYILWEYSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.37
• 重原子数：
  71
• 可旋转键数：
  18
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1-[(2R,4R,5S)-4-[[[(2R,3S,5R)-3-[tert-butyl(diphenyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyamino]methyl]-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 在 盐酸 、 四丁基氟化铵 作用下， 生成
  参考文献：
  名称：

  Oligonucleosides: synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences

  摘要：

  DOI：

  10.1021/ja00036a076
• 作为产物：
  描述：

  5'-O-tritylthymidine 在 甲基三苯氧基碘磷 、 Bis-(trimethylzinn)-benzpinakolat 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 38.0h， 生成 1-[(2R,4R,5S)-4-[[[(2R,3S,5R)-3-[tert-butyl(diphenyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyamino]methyl]-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  Intermolecular radical CC bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides

  摘要：

  An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.

  DOI：

  10.1016/s0040-4039(00)79047-2

文献信息

• Intermolecular radical CC bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides
  作者：Françoise Debart、Jean-Jacques Vasseur、Yogesh S. Sanghvi、P. Dan Cook

  DOI：10.1016/s0040-4039(00)79047-2

  日期：1992.5

  An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.
• Oligonucleosides: synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences
  作者：Jean Jacques Vasseur、Francoise Debart、Yogesh S. Sanghvi、P. Dan Cook

  DOI：10.1021/ja00036a076

  日期：1992.5