diacryloyl-2,6-diaminopyridine | 147075-91-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diacryloyl-2,6-diaminopyridine
• 英文别名: 2,6-bis(acrylamido)pyridine；2,6-bis(acrylamino)pyridine；2,6-diacryloylaminopyridine；N-[6-(prop-2-enoylamino)pyridin-2-yl]prop-2-enamide
• CAS: 147075-91-0
• 化学式: C₁₁H₁₁N₃O₂
• 分子量: 217.227
• InChiKey: DYFKVBQGIGQYCJ-UHFFFAOYSA-N

物化性质

• 沸点：
  509.2±50.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N,N′,N′-四乙基二乙烯三胺 、 diacryloyl-2,6-diaminopyridine 以 甲醇 为溶剂， 反应 48.0h， 生成 3-[bis[2-(diethylamino)ethyl]amino]-N-[6-[3-[bis[2-(diethylamino)ethyl]amino]propanoylamino]pyridin-2-yl]propanamide
  参考文献：
  名称：

  Reversible Catalyst Supporting via Hydrogen-Bonding-Mediated Self-Assembly for Atom Transfer Radical Polymerization of MMA

  摘要：

  Atom transfer radical polymerization (ATRP) is a very useful living/controlled radical polymerization process for polymer synthesis, but its products are contaminated with transition metal catalyst residue. Catalyst immobilization on solids via covalent binding has the advantages of easy catalyst separation and reuse, but it deteriorates the control of the polymerization due to the slowed radical deactivation, which causes chain termination and uncontrolled propagation. In this paper, we report a reversible catalyst supporting concept via hydrogen-bonding-mediated self-assembly. The support acts as a "catalyst sponge" releasing the catalyst as free molecules at elevated temperatures for effective catalysis but absorbing the catalyst after the polymerization for separation. The support was polystyrene gel functionalized with maleimide or thymine units, and the catalyst was tethered on a diaminopyridine unit. A triple hydrogen bond array formed between maleimide or thymine and diaminopyridine at room temperature but broke at elevated temperatures. At 60 degreesC, the reversibly supported catalyst efficiently polymerized MMA in a well-controlled living manner, yielding PMMA with polydispersity as low as those by unsupported catalysts. The recycled catalysts still mediated MMA polymerization with a much improved control.

  DOI：

  10.1021/ma035322c
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 丙烯酰氯 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 2.25h， 以66%的产率得到diacryloyl-2,6-diaminopyridine
  参考文献：
  名称：

  Novel polymernanowires with triple hydrogen-bonding sites fabricated by metallogel template polymerization and their adsorption of thymidine

  摘要：

  以过氧化苯甲酰（BPO）为引发剂，在 Ag（I）配位的有机凝胶中通过基于金属凝胶模板聚合的一锅程序制备了具有三重氢键位点的新型聚合物纳米线。利用红外光谱、扫描电子显微镜和透射电子显微镜对产品进行了表征。实验结果表明，凝胶纤维是聚合的关键模板。由于模板在聚合过程中发生降解，金属凝胶纳米纤维被转录成聚合物纳米线。用这种方法合成的聚合物纳米线含有由单体二丙烯酰基-2,6-二氨基吡啶（DADAP）引入的三重氢键位点；它们可用作吸附剂，从稀 THF 溶液中 "吸收 "胸苷。高效的吸附性能和可重复使用的特性使它们成为生物吸附相关应用的理想候选材料。

  DOI：

  10.1039/c0sm00857e

文献信息

• MOLECULARLY IMPRINTED POLYMERS
  申请人：Hearn Milton T. W.

  公开号：US20120052757A1

  公开（公告）日：2012-03-01

  The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

  本发明提供了设计分子印迹聚合物（MIPs）的方法，这些方法在从各种生物加工原料和废弃物中提取生物活性化合物方面具有应用。本发明进一步针对由本发明方法设计的MIPs。
• METHOD FOR PRODUCING A RADIOACTIVE TRACER
  申请人：Perollier Céline

  公开号：US20130053607A1

  公开（公告）日：2013-02-28

  A method for preparing a radioactive tracer provided with a radioactive fluorine isotope, including providing a precursor of the radioactive tracer, comprising at least one leaving group completely or partially formed by a labelling entity, wherein said leaving group can be moved by a fluoride ion, providing a molecularly imprinted polymer dedicated to the molecular recognition of at least the aforementioned labelling entity, exposing the precursor to a radioactive fluoride ion source under conditions suitable for movement of the leaving group by a radioactive fluoride ion, placing the mixture resulting from step (iii) in contact with the molecularly imprinted polymer under conditions suitable for the recognition of the labelling entity, and obtaining a solution containing the radioactive tracer provided with a radioactive isotope of fluorine obtained at the end of step (iii).

  一种制备具有放射性氟同位素的放射性示踪剂的方法，包括提供放射性示踪剂的前体，包括至少一个由标记实体完全或部分形成的离去基团，其中所述离去基团可以被氟离子移动，提供专门用于分子识别至少上述标记实体的分子印迹聚合物，将前体置于适宜于通过放射性氟离子移动离去基团的条件下的放射性氟离子源中，将步骤（iii）产生的混合物与分子印迹聚合物接触，在适宜于识别标记实体的条件下，获得含有放射性氟同位素的放射性示踪剂的溶液，该溶液是在步骤（iii）结束时获得的。
• KIT USEFUL FOR DETECTING, SEPARATING AND/OR CHARACTERIZING A MOLECULE OF INTEREST
  申请人：Le Foll Alexandra

  公开号：US20110263446A1

  公开（公告）日：2011-10-27

  A kit for separating and/or characterizing at least one molecule A of interest, the kit including: (i) a compound having the general formula: B—(R) n —Z in which: B represents a hydrogen atom or a detectable labeling entity; R represents a C 1 -C 10000 hydrocarbon unit which may be polymeric or non-polymeric and optionally incorporates one or more heteroatoms, chosen from N, O, S, Br, Cl, F, P, B, Si and/or one or more metals; n represents 0 or 1, with n being equal to 1 when B represents a hydrogen atom; and Z represents a functional group capable of reacting in a click chemistry reaction in order to form a linking function L click ; and (ii) a molecularly imprinted polymer dedicated to the molecular recognition of at least said linking function L click .

  一个用于分离和/或表征至少一种感兴趣的分子A的试剂盒，该试剂盒包括：(i) 具有一般公式的化合物：B—(R)n—Z，其中：B代表氢原子或可检测的标记实体；R代表C1-C10000碳氢化合物单元，可以是聚合物或非聚合物，并且可以选择性地包含一个或多个异原子，选自N、O、S、Br、Cl、F、P、B、Si和/或一个或多个金属；n表示0或1，当B代表氢原子时，n等于1；Z代表能够在点击化学反应中发生反应以形成连接功能Lclick的官能团；以及(ii) 专门用于分子识别至少所述连接功能Lclick的分子印迹聚合物。
• [EN] COMPOUNDS AND SENSOR FOR DETECION OF POLYCYCLIC AROMATIC HYDROCARBONS<br/>[FR] COMPOSES ET CAPTEURS DESTINES A LA DETECTION D'HYDROCARBURES AROMATIQUES POLYCYCLIQUES
  申请人：CENTRAL SCIENCE LAB CSL

  公开号：WO2005090379A1

  公开（公告）日：2005-09-29

  Compound for binding an electron deficient polycyclic aromatic hydrocarbon (PAH) comprising a 'tweezer' of formula I: wherein is any C15-45 planar skeleton comprised of a saturated fused alicyclic (3) to (8) ring system each X is a linking group; and each is a group Ar substituted by a total of from (1) up to 20 halogen atoms each n is a whole number integer from (1) to (3) and the sum of n is (2) to (6); A is a group or moiety selected from lipophilic groups such as C4-20 aliphatic or alicyclic saturated or unsaturated hydrocarbon groups; T is an optional support or detection element and m is (0) or (1); and k is (0) or is a whole number integer selected from (1) to (3); wherein the groups Ar are pendant to at least two different rings of the planar B skeleton and are located on the same face of the planar B skeleton forming, together with B, a pocket suitable for receiving and binding a guest PAH species; a process for the preparation thereof; a polymer comprising immobilised compound of formula I and method for the preparation thereof; a method for detecting a PAH using a compound of formula I; a PAH sensor comprising a compound of formula I; method for PAH detection therewith; and uses thereof.

  用于结合电子不足多环芳烃（PAH）的化合物，包括公式I中的“镊子”：其中任何C15-45平面骨架由饱和融合脂环（3）到（8）环系统组成，每个X是连接基团；每个是由总共（1）到（20）个卤原子取代的Ar基团，每个n是从（1）到（3）的整数，n的总和为（2）到（6）；A是从疏水基团中选择的基团或基团，例如C4-20脂肪或脂环饱和或不饱和碳氢基团；T是可选的支持或检测元素，m为（0）或（1）；k为（0）或从（1）到（3）中选择的整数；其中基团Ar挂接到平面B骨架的至少两个不同环上，并位于平面B骨架的同一面上，与B一起形成一个适用于接收和结合宿主PAH物种的口袋；其制备方法；包含公式I固定化合物的聚合物及其制备方法；使用公式I化合物检测PAH的方法；包含公式I化合物的PAH传感器；用于PAH检测的方法；以及其用途。
• MOLECULARLY IMPRINTED POLYMERS FOR THE RECOGNITION OF GLUTATHIONE GSH, METHODS FOR PREPARING SAME AND USES THEREOF
  申请人：Perollier Celine

  公开号：US20100234565A1

  公开（公告）日：2010-09-16

  The present invention relates to new molecularly imprinted polymers which are suitable for the selective recognition of glutathione GSH and/or of an analog thereof, and in particular which are of use for the treatment of media comprising in particular a mixture of glutathione GSH, and/or of an analog thereof, with GSH adducts.

  本发明涉及新的分子印迹聚合物，适用于选择性识别谷胱甘肽GSH和/或其类似物，特别是用于处理包括谷胱甘肽GSH和/或其类似物与GSH加合物的介质。