1-((1S,3R)-3-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-naphthalen-2-ol | 1226970-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-((1S,3R)-3-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-naphthalen-2-ol
• CAS: 1226970-60-0
• 化学式: C₂₅H₂₁NO
• 分子量: 351.448
• InChiKey: KQCOOEXBMJGBTA-RDGATRHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  27.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-萘酚 、 (3R)-3-phenyl-3,4-dihydroisoquinoline 以 水 为溶剂， 以75%的产率得到1-((1S,3R)-3-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-naphthalen-2-ol
  参考文献：
  名称：

  Synthesis of Chiral 1,3-Disubstituted Tetrahydroisoquinolines and Their Use in the Asymmetric Addition of Diethylzinc to Aldehydes

  摘要：

  The effects of modifications on three sites of 1-(1,2,3,4-tetrahydro-isoquinolin-1-yl)-naphthalen-2-ol (THIQNOL) chiral ligands the asymmetric diethylzinc additions were examined. The studies showed that modifications at the nitrogen only reduce the efficiency of these types of ligands, whereas modifications at the 3-position of the 1,2,3,4-tetrahydroisoquinoline ring and the 3-position of the naphthol ring can lead to chiral ligands which provide better enantioselectivities. In general, the use of a simple phenyl group on the 1,2,3,4-tetrahydroisoquinoline ring and either a phenyl or methoxyphenyl on the naphthol ring generates more effective chiral ligands for the asymmetric addition of diethylzinc to aldehydes.

  DOI：

  10.3987/com-09-s(s)123

文献信息

• Synthesis of Chiral 1,3-Disubstituted Tetrahydroisoquinolines and Their Use in the Asymmetric Addition of Diethylzinc to Aldehydes
  作者：Chao-Jun Li、Patricia D. MacLeod、Amy M. Reckling

  DOI：10.3987/com-09-s(s)123

  日期：——

  The effects of modifications on three sites of 1-(1,2,3,4-tetrahydro-isoquinolin-1-yl)-naphthalen-2-ol (THIQNOL) chiral ligands the asymmetric diethylzinc additions were examined. The studies showed that modifications at the nitrogen only reduce the efficiency of these types of ligands, whereas modifications at the 3-position of the 1,2,3,4-tetrahydroisoquinoline ring and the 3-position of the naphthol ring can lead to chiral ligands which provide better enantioselectivities. In general, the use of a simple phenyl group on the 1,2,3,4-tetrahydroisoquinoline ring and either a phenyl or methoxyphenyl on the naphthol ring generates more effective chiral ligands for the asymmetric addition of diethylzinc to aldehydes.