5-(2-氨基乙基)-1,2,4-噁二唑-3-羧酸乙酯 | 790207-00-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-(2-氨基乙基)-1,2,4-噁二唑-3-羧酸乙酯
• 中文别名: 5-(2-氨乙基)-1,2,4-恶二唑-3-羧酸乙酯
• 英文名称: Ethyl 5-(2-aminoethyl)-1,2,4-oxadiazole-3-carboxylate
• CAS: 790207-00-0
• 化学式: C₇H₁₁N₃O₃
• 分子量: 185.18
• InChiKey: PFCATDAIDKUEFO-UHFFFAOYSA-N

物化性质

• 沸点：
  308.8±44.0 °C(Predicted)
• 密度：
  1.238

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  91.2
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

文献信息

• Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates
  申请人：——

  公开号：US20040019215A1

  公开（公告）日：2004-01-29

  Disclosed are efficient and scalable processes for preparing 1,2,4- and 1,3,4-oxadiazole carboxylates from readily available starting materials.

  披露了一种高效且可扩展的过程，用于从易得的起始材料制备1,2,4-和1,3,4-噁二唑羧酸酯。
• Large scale synthesis of 1,2,4- and 1,3,4- oxadiazole carboxylates
  申请人：Kolb C. Hartmuth

  公开号：US20050154211A1

  公开（公告）日：2005-07-14

  Disclosed are efficient and scalable processes for preparing 1,2,4- and 1,3,4-oxadiazole carboxylates from readily available starting materials.

  本发明揭示了一种从易得的起始物质制备1,2,4-和1,3,4-氧代二唑羧酸酯的高效可扩展工艺。
• [EN] MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'OREXINE D'URÉE MACROCYCLIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2022094012A1

  公开（公告）日：2022-05-05

  The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及宏环脲化合物，其是睡觉醒来素受体的激动剂。本发明还涉及所述化合物在潜在的涉及睡觉醒来素受体的神经和精神障碍和疾病的治疗或预防中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在涉及睡觉醒来素受体的这些疾病的预防或治疗中的用途。
• US6951946B2
  申请人：——

  公开号：US6951946B2

  公开（公告）日：2005-10-04