5-(2-氨基乙基)吡啶-2(1H)-酮 | 910400-60-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-(2-氨基乙基)吡啶-2(1H)-酮
• 英文名称: 5-(2-Aminoethyl)pyridin-2(1H)-one
• 英文别名: 5-(2-aminoethyl)-1H-pyridin-2-one
• CAS: 910400-60-1
• 化学式: C₇H₁₀N₂O
• mdl: MFCD08449284
• 分子量: 138.17
• InChiKey: BWPNHPUSOYZHGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  375.9±24.0 °C(Predicted)
• 密度：
  1.107±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

文献信息

• NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：BERNHART Claude

  公开号：US20100222319A1

  公开（公告）日：2010-09-02

  The disclosure relates to compounds of formula (I): wherein A, Z, Z′, L, R 2 and R 3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.

  该公开涉及到式(I)的化合物： 其中A、Z、Z'、L、R2和R3如公开所定义，以及包含该化合物的组合物，以及用于其制备和治疗用途的方法。
• [EN] PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] COMPOSES DE PYRAZOLO[3,4-B]PYRIDINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHODIESTERASE
  申请人：GLAXO GROUP LTD

  公开号：WO2004024728A2

  公开（公告）日：2004-03-25

  The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.