| 1268318-56-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• CAS: 1268318-56-4
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: QODRCZJHJBHBEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2'-甲氧基肉桂醛 在 四氢吡咯 、 水 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Secondary amine catalyzed retro-aldol reactions of enals and enones: one-pot conversion of enals to α-substituted derivatives

  摘要：

  A practical synthetic procedure to hydrolytically cleave the CC-double bond of alpha,beta-unsaturated aldehydes and ketones has been developed. Secondary amines are employed as organocatalysts for the retro-aldol process under simple and mild reaction conditions. Beside the generation of the parent aromatic aldehydes, the synthetic procedure has been successfully used in a one-pot reaction sequence to convert simple cinnamaldehydes into their alpha-aryl/alkyl substituted derivatives. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.039

文献信息

• Secondary amine catalyzed retro-aldol reactions of enals and enones: one-pot conversion of enals to α-substituted derivatives
  作者：Dieter Enders、Thanh V. Nguyen

  DOI：10.1016/j.tetlet.2012.02.039

  日期：2012.4

  A practical synthetic procedure to hydrolytically cleave the CC-double bond of alpha,beta-unsaturated aldehydes and ketones has been developed. Secondary amines are employed as organocatalysts for the retro-aldol process under simple and mild reaction conditions. Beside the generation of the parent aromatic aldehydes, the synthetic procedure has been successfully used in a one-pot reaction sequence to convert simple cinnamaldehydes into their alpha-aryl/alkyl substituted derivatives. (C) 2012 Elsevier Ltd. All rights reserved.