diethyl 1-acetyloxybutylphosphonate | 40568-81-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl 1-acetyloxybutylphosphonate
• 英文别名: (1-acetoxy-butyl)-phosphonic acid diethyl ester；(1-Acetoxy-butyl)-phosphonsaeure-diaethylester；1-Acetoxy-butylphosphonsaeure-diethylester；Diethyl(1-acetoxybutyl)phosphonat；1-(Diethoxyphosphoryl)butyl acetate；1-diethoxyphosphorylbutyl acetate
• CAS: 40568-81-8
• 化学式: C₁₀H₂₁O₅P
• 分子量: 252.247
• InChiKey: AOJGLFYWZWHGFL-UHFFFAOYSA-N

物化性质

• 沸点：
  101-102 °C(Press: 1 Torr)
• 密度：
  1.076±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl 1-acetyloxybutylphosphonate 在 五氯化磷 、 三乙胺 作用下， 以 乙醚 为溶剂， 生成 <1-Acetoxy-butylphosphonsaeure>-monoaethylester
  参考文献：
  名称：

  对硝基苯基α-乙酰氧基烷基膦酸酯的合成。

  摘要：

  DOI：

  10.1021/jm00329a051
• 作为产物：
  描述：

  乙烯酮 、 1-羟基丁基膦酸二乙酯 在 boron fluoride ether 作用下， 生成 diethyl 1-acetyloxybutylphosphonate
  参考文献：
  名称：

  Preparation and Properties of Diethyl Acetoxyalkylphosphonates

  摘要：

  DOI：

  10.1021/ja01565a054

文献信息

• [EN] NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVELLES COMPOSITIONS HETEROCYCLIQUES ET LEUR UTILISATION EN MEDECINE; PROCEDES DE LEUR FABRICATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1999016758A1

  公开（公告）日：1999-04-08

  (EN) The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of general formula (I), their derivatives, their analogs, their tautomeric forms, their stereosomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.(FR) La présente invention concerne de nouveaux composés anti-obésité et hypocholestérolémiques, leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables les contenant. Plus particulièrement, cette invention se rapporte à de nouveaux acides alkylcarboxyliques $g(b)-aryl-$g(a)-oxysubstitués qui correspondent à la formule générale (I), ainsi qu'à leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables et à des compositions pharmaceutiquement acceptables les contenant.

  本发明涉及新型抗肥胖和降低胆固醇化合物，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化物和包含它们的药学上可接受的组合物。更具体地说，本发明涉及一般式（I）的新型$g(b)-芳基-$g(a)-氧基取代的烷基羧酸，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化物和包含它们的药学上可接受的组合物。
• Novel heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
  申请人：DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR INC.

  公开号：US20010027198A1

  公开（公告）日：2001-10-04

  The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (1), their derivatives, their analogs, their tautomeric forms, their stereosomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. 1 The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, novel intermediates and pharmaceutical compositions containing them.

  本发明涉及新型抗肥胖和降胆固醇化合物、它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂及含有它们的药学上可接受的组合物。更具体地，本发明涉及一般式（1）的新型β-芳基-α-氧基取代烷基羧酸、它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂及含有它们的药学上可接受的组合物。本发明还涉及制备上述新型化合物、类似物、衍生物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂、新型中间体和含有它们的制药组合物的方法。
• Organophosphorus Chemistry. Addition Reactions of Diethyl Phosphonate and the Oxidation of Triethyl Phosphite¹
  作者：M. S. KHARASCH、ROBERT A. MOSHER、IRVING S. BENGELSDORF

  DOI：10.1021/jo01076a035

  日期：1960.6
• An Efficient Route to Chiral α- and β-Hydroxyalkanephosphonates
  作者：Oscar Pàmies、Jan-E. Bäckvall

  DOI：10.1021/jo026888m

  日期：2003.6.1

  Enzymatic kinetic resolution of alpha- and beta-hydroxyphosphonates in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic hydroxyphosphonates were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and yield up to 87%).
• Nesterov,L.V.; Krepysheva,N.E., Journal of general chemistry of the USSR, 1976, vol. 46, p. 1904 - 1909
  作者：Nesterov,L.V.、Krepysheva,N.E.

  DOI：——

  日期：——