3,3,9,9-tetrabutyl-2,4,8,10-tetraoxa-3,9-distannaspiro[5,5]undecane | 56541-80-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 英文名称: 3,3,9,9-tetrabutyl-2,4,8,10-tetraoxa-3,9-distannaspiro[5,5]undecane
• 英文别名: 3,3,9,9-tetrabutyl-2,4,8,10-tetraoxa-3,9-distanna-spiro[5.5]undecane；3,3,9,9-Tetrabutyl-2,4,8,10-tetraoxa-3,9-distanna-spiro[5.5]undecan；3,3,9,9-tetrabutyl-2,4,8,10-tetraoxa-3,9-distannaspiro[5.5]-undecane
• CAS: 56541-80-1
• 化学式: C₂₁H₄₄O₄Sn₂
• 分子量: 597.998
• InChiKey: WTWVAGWEKFTPRR-UHFFFAOYSA-N

物化性质

• 沸点：
  466.2±55.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.15
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  季戊四醇 、 二正丁基氧化锡 以 甲苯 为溶剂， 反应 24.0h， 以88%的产率得到3,3,9,9-tetrabutyl-2,4,8,10-tetraoxa-3,9-distannaspiro[5,5]undecane
  参考文献：
  名称：

  Kinetic and biocompatibility investigation on the catalytic ring opening polymerization of l-lactide in bulk using cyclic Bu2Sn initiators derived from ethylene glycol, pentaerythritol and cloisite 30B

  摘要：

  In the present work, considering a green approach, PLLA was synthesized by the ring-opening polymerization of L-LA using various cyclic initiators (2,2-dibutyl-2-stanna-1,3-dioxacyclo ethane (1), spirocyclic tin (3) and cloisite modified tin (5)). PLLA was characterized by size exclusion chromatography, differential scanning calorimetry, H-1 and C-13 NMR, XRD and MALDI-TOF. The molecular weight distribution was narrow (<1.5) for both low and high molecular weights (>85,000 g/mol). An X-ray study showed the crystalline nature of PLLA, irrespective of the different types of initiators and polymerization conditions. A kinetic investigation showed that all polymerizations were first order with respect to the monomer and no termination reactions occurred during the polymerization. MALDI-TOF spectra of PLLA chains doped with Na+ and K+ cations show that the PLLA prepared using initiators 1 and 3 have hydroxyl and carboxyl end groups without incorporation of tin. The MALDI-TOF spectrum of PLLA prepared using initiator 5 also enabled the simultaneous detection of the linear and cyclic structure of PLLA without tin. Biocompatible and biodegradable PLLA was obtained, which could be used for biomedical applications. (C) 2019 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2019.114202

文献信息

• Hydrocarbon tin alcoholates
  申请人：UNION CARBIDE &

  公开号：US02583084A1

  公开（公告）日：1952-01-22
• Kinetic and biocompatibility investigation on the catalytic ring opening polymerization of l-lactide in bulk using cyclic Bu2Sn initiators derived from ethylene glycol, pentaerythritol and cloisite 30B
  作者：Kavita K. Mohite、Baijayantimala Garnaik

  DOI：10.1016/j.poly.2019.114202

  日期：2020.1

  In the present work, considering a green approach, PLLA was synthesized by the ring-opening polymerization of L-LA using various cyclic initiators (2,2-dibutyl-2-stanna-1,3-dioxacyclo ethane (1), spirocyclic tin (3) and cloisite modified tin (5)). PLLA was characterized by size exclusion chromatography, differential scanning calorimetry, H-1 and C-13 NMR, XRD and MALDI-TOF. The molecular weight distribution was narrow (<1.5) for both low and high molecular weights (>85,000 g/mol). An X-ray study showed the crystalline nature of PLLA, irrespective of the different types of initiators and polymerization conditions. A kinetic investigation showed that all polymerizations were first order with respect to the monomer and no termination reactions occurred during the polymerization. MALDI-TOF spectra of PLLA chains doped with Na+ and K+ cations show that the PLLA prepared using initiators 1 and 3 have hydroxyl and carboxyl end groups without incorporation of tin. The MALDI-TOF spectrum of PLLA prepared using initiator 5 also enabled the simultaneous detection of the linear and cyclic structure of PLLA without tin. Biocompatible and biodegradable PLLA was obtained, which could be used for biomedical applications. (C) 2019 Elsevier Ltd. All rights reserved.